DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and cest-12

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_499576.4	Gene:	cest-12 / 176642	WormBaseID:	WBGene00013540	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	111/496 - (22%)
Similarity:	200/496 - (40%)	Gaps:	123/496 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VSLLLVLQSVVESRVRGRQYDEEKDTIVELPTLGSIQGKILETAWTKREVLQ-----FVDVRYAE 68
            ::|.....:|..::.:.:..:::.:.:....:.||:||:.:.....:.::..     |..:.|.:
Worm     9 LTLFSAFSNVSNAQYQNQNQNQQSNYVTVSCSQGSVQGRQVNLGNDQSQLYSGQANAFTGIPYCQ 73

  Fly    69 PPTGLHRFKAPRPIEPWEDVM-DATAEKIGCPSVVSMDSLRRLDDVLDVEDCLTMTITTP---NV 129
            .|.|..|.:.|:|:..:...: |||..:..||.:.:.....        ||||.:.:.||   |.
Worm    74 APVGNLRLQPPQPLNQFNTTLHDATYFRPKCPQLNAGGPTN--------EDCLYLNVYTPQAGNT 130

  Fly   130 TSRLPVLVYIHGEYLYEGSNSEAPPD-----YLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAG 189
            .:.|.|||.|.|...:.....:...:     .|:::.:|:||.|||:|..||.:|.|:.:..|.|
Worm   131 NANLSVLVLIDGSNGFSNGGCDQNQEKGIISNLVQRQIVVVTMQYRIGALGFFTTYTNSVQSNLG 195

  Fly   190 FLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPI 254
            .||...|::::|..|..|||:|:::|||||..||.......|||:.| .||:|.|..|||    :
Worm   196 MLDQVQAMRWIKTEIVNFGGNPNQITVAGQDDGACAVSAHCLSPMSQ-NLFNQAIVQSGS----V 255

  Fly   255 FLEEDPRKHAQEIAKKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTG-----G 314
            :...:|   ...:......::.|.|.:                    .::|:.|.|:.|     |
Worm   256 YSCYNP---TPAVPTNPQVQVTTPRPM--------------------YDQSNTGYGNAGYQNNYG 297

  Fly   315 IQFTIGGPSGVLPKHPYDLMLETNFSYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNT---- 375
            .|     |..:.....|:   ..|..|        :..|:.|.:.:.|     |..|::|.
Worm   298 YQ-----PQPITSTSSYN---SANAQY--------DDPSQQLAQTLCN-----ISPDQWNNGQTQ 341

  Fly   376 ------YNY-IDHVI-RQTVGTDKTMLL---TSFVTHDFFNRNLMENGTFDTLIPRLIDVAGTLN 429
                  .|| :|..: :|..|.:.|.::   |||                   :|..||...|..
Worm   342 NIQNCMKNYTVDFFVNQQPGGPNATWMIVRDTSF-------------------LPGSIDSLTTRR 387

  Fly   430 HKLPVLLA-------------LNMNNKHNPDNTFLYSFDYA 457
            ..:|:::.             :|.....:|:|...:.||:|
Worm   388 PNIPIIIGTVQDEDADYAFKLINTGKGSDPNNLDDWIFDFA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	109/474 (23%)
cest-12	NP_499576.4	Abhydrolase	37..>400	CDD:389770	103/438 (24%)
cest-12	NP_499576.4	Abhydrolase	<678..774	CDD:389770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810