DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and Ces1c

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	566	Identity:	154/566 - (27%)
Similarity:	248/566 - (43%)	Gaps:	102/566 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSM 104
            |.|.:.||.:.....::.|..|:.|.:|:||.|..||..|:|.|||..|.:||:    .|.:.|.
Mouse    29 TQGKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATS----YPPMCSQ 89

  Fly   105 DS--LRRLDDVLDV----------EDCLTMTITTP---NVTSRLPVLVYIHGEYLYEGSNSEAPP 154
            |:  .:.|.|:...          ||||.:.|.:|   ..:|:|||:|:|||..|..|..|  |.
Mouse    90 DAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGAS--PY 152

  Fly   155 DYL---LEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTV 216
            :.|   ..::||:||.|||||.:|..||..:..|||...||...||::|:..|..|||:|..||:
Mouse   153 NGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTI 217

  Fly   217 AGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCKMVTVRDL 281
            .|:..|.....:|.||| :.:.|||:.|..||..|.....:::.:...:.||..:.|...:...:
Mouse   218 FGESSGGISVSVLVLSP-LGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSSAAM 281

  Fly   282 NTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETNF-SYPAMG 345
            ..||.:.|..||        ||.|...:.:...:...|.|.  ||||.|.:::.|.:| :.|.:.
Mouse   282 VQCLRQKTESEL--------LEISGKLVQYNISLSTMIDGV--VLPKAPEEILAEKSFNTVPYIV 336

  Fly   346 GCPKNAGSRVLNEIVDNDF-EGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFFNRNLM 409
            |..|.....::..::.|.. |||:.::                  ..::||..|  |...|.:
Mouse   337 GFNKQEFGWIIPMMLQNLLPEGKMNEE------------------TASLLLRRF--HSELNIS-- 379

  Fly   410 ENGTFDTLIPRLI------------------DVAGTLNHKLPVLLALNMNNKHNPDNTFLYSFDY 456
                 :::||.:|                  |:.|.:...:|.:| |:.:.:....:|::|.|.|
Mouse   380 -----ESMIPAVIEQYLRGVDDPAKKSELILDMFGDIFFGIPAVL-LSRSLRDAGVSTYMYEFRY 438

  Fly   457 AGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLSRPDQSMAHRMVELWTNFVISG 521
            ...|...|.         |........||..::|..|......|..:.:::..:::.|.||..:|
Mouse   439 RPSFVSDKR---------PQTVEGDHGDEIFFVFGAPLLKEGASEEETNLSKMVMKFWANFARNG 494

  Fly   522 NPLGSARVGYWPPMTTLYGPYMRIDDTMTIGGNYFTEFSATLSDEE 567
            ||.|.. :.:||......| |::|..|        |:.:..|..||
Mouse   495 NPNGEG-LPHWPEYDEQEG-YLQIGAT--------TQQAQRLKAEE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	150/555 (27%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	151/559 (27%)
		Aes	<121..>234	CDD:223730	46/114 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750