DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and Cel

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_034015.1	Gene:	Cel / 12613	MGIID:	88374	Length:	599	Species:	Mus musculus

Alignment Length:	572	Identity:	147/572 - (25%)
Similarity:	229/572 - (40%)	Gaps:	130/572 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LGSI--QGKILETAWTKREVL--QFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSV 101
            ||::  :|..:|....|..:|  ..||:....|.......:.|:....|:..:.||..|..|
Mouse    23 LGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATNFKKRC--- 84

  Fly   102 VSMDSLRRLDDVLDVEDCLTMTITTP----NVTSRLPVLVYIHG---------------EYLYEG 147
              :.:....|:....||||.:.|..|    .|:..|||:|:|:|               .|||:|
Mouse    85 --LQATITQDNTYGQEDCLYLNIWVPQGRKQVSHNLPVMVWIYGGAFLMGSGQGANFLKNYLYDG 147

  Fly   148 SNSEAPPDYLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPS 212
            .      :.....:|::||..||:||.|||||....:|||.|..|..:|:.:||..|..|||||.
Mouse   148 E------EIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPD 206

  Fly   213 RVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCKMVT 277
            .:|:.|:..|||...|.|||| ..:||..:.|..||.|:.|..::::|...|:.||||..|....
Mouse   207 NITIFGESAGAASVSLQTLSP-YNKGLIRRAISQSGMALSPWAIQKNPLFWAKTIAKKVGCPTED 270

  Fly   278 VRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETNFSYP 342
            ...:..|| ::|....||...:..::|.:..:.|                             |.
Mouse   271 TGKMAACL-KITDPRALTLAYKLPVKKQEYPVVH-----------------------------YL 305

  Fly   343 AMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNY---IDHV---------------------I 383
            |.  .|          ::|.||   ||||..|.||.   ||::                     .
Mouse   306 AF--IP----------VIDGDF---IPDDPINLYNNTADIDYIAGINNMDGHLFATIDVPAVDKT 355

  Fly   384 RQTVGTDKTMLLTS-----------FVTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHKLPVLLA 437
            :|||..:....|.|           ..|.|.:..:..::.:.:.:...::.....:...:|..:|
Mouse   356 KQTVTEEDFYRLVSGHTVAKGLKGAQATFDIYTESWAQDPSQENMKKTVVAFETDVLFLIPTEIA 420

  Fly   438 LNMNNKH-NPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLSR 501
            |..:..| ....|:.|.|.:......|           |...|....|:..|:|..|.......|
Mouse   421 LAQHKAHAKSAKTYSYLFSHPSRMPIY-----------PKWMGADHADDLQYVFGKPFATPLGYR 474

  Fly   502 P-DQSMAHRMVELWTNFVISGNP-LGSARV-GYWPPMTTLYGPYMRIDDTMT 550
            | |::::..|:..||||..||:| :|::.| .:|.|.|...|.|:.|..|:|
Mouse   475 PQDRAVSKAMIAYWTNFARSGDPNMGNSPVPTHWYPYTLENGNYLDITKTIT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	147/572 (26%)
Cel	NP_034015.1	COesterase	26..542	CDD:278561	145/569 (25%)
		Aes	<117..>247	CDD:223730	52/136 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..599
		4 X 11 AA tandem repeats, O-glycosylated region	559..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832808
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740