DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and Ache

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	601	Identity:	157/601 - (26%)
Similarity:	242/601 - (40%)	Gaps:	137/601 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLVLQSVV--ESRVRGRQYDEEKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPPTGL 73
            ||.:|.|::  .:|..||   |:...:|.:.. |.::|..|:.  ....|..|:.:.:||||.|.
Mouse    17 LLFLLLSLLGGGARAEGR---EDPQLLVRVRG-GQLRGIRLKA--PGGPVSAFLGIPFAEPPVGS 75

  Fly    74 HRFKAPRPIEPWEDVMDATAEKIGCPSVVSMDSL-------------RRLDDVLDVEDCLTMTIT 125
            .||..|.|..||..|:|||..:..|...|  |:|             |.|.     ||||.:.:.
Mouse    76 RRFMPPEPKRPWSGVLDATTFQNVCYQYV--DTLYPGFEGTEMWNPNRELS-----EDCLYLNVW 133

  Fly   126 T--PNVTSRLPVLVYIHGEYLYEGSNSEAPPD--YLLE-KDVVLVTPQYRLGPFGFLSTK-TDEI 184
            |  |...|..|||::|:|...|.|:.|....|  :|.: :..|||:..||:|.||||:.. :.|.
Mouse   134 TPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREA 198

  Fly   185 PGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIA--HLLTLSPVVQRGLFHQVIYHS 247
            |||.|.||..||||:|:..|..|||||..||:.|:..|||..  |:|:|.   .|.|||:.:..|
Mouse   199 PGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLP---SRSLFHRAVLQS 260

  Fly   248 GSAIMP--IFLEEDPRKHAQEIAKKADCKMVTV----RDLNTCLMELTALELLTAFMEHALEKSD 306
            |:...|  .....:.|:.|..:|:...|.....    .:|..||....|.:|    ::|...
Mouse   261 GTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDL----VDHEWH--- 318

  Fly   307 LGIGHTGGIQFTIGGPSGVLPKHPYDLMLETNFSYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDD 371
                              |||:       |:.|.:..:             .:||.||....|:.
Mouse   319 ------------------VLPQ-------ESIFRFSFV-------------PVVDGDFLSDTPEA 345

  Fly   372 EYNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFF--NRNLMENGTF----DTLIPRLIDVAGT--- 427
            ..||.::.|..:...|..|:......:....|.  |.:|:....|    ...:|:..|:|..
Mouse   346 LINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVV 410

  Fly   428 ------LNHKLPVLLALNMN---NKHN---------------PDNTFLYSFDYAGEFNRYKEMDE 468
                  |:.:.|..|...|:   ..||               ....:.|.|::           .
Mouse   411 LHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEH-----------R 464

  Fly   469 ETNLQSPFKAGVSLTDEALYLFPYP-EHVTRLSRPDQSMAHRMVELWTNFVISGNPLG--SARVG 530
            .:.|..|...||....|..::|..| :.....:..::..|.|:::.||||..:|:|..  .::..
Mouse   465 ASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSP 529

  Fly   531 YWPPMTTLYGPYMRID 546
            .|||.||....|:.::
Mouse   530 QWPPYTTAAQQYVSLN 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	149/579 (26%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	149/578 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832858
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840