DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and Ces1d

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	155/578 - (26%)
Similarity:	246/578 - (42%)	Gaps:	109/578 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PTLGSIQGKIL----ETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCP 99
            |.:.:::||:|    ......:.|..|:.:.:|:||.|..||..|:|.|||..|.:.|:    .|
  Rat    24 PVVNTVKGKVLGKYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTS----YP 84

  Fly   100 SVVSMDSL-----------RRLDDVLDV-EDCLTMTITTP---NVTSRLPVLVYIHGEYLYEGSN 149
            .:.|.|::           |:.:..|.. ||||.:.:.||   ...|||||:|:|||..|..|..
  Rat    85 PMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVGGA 149

  Fly   150 SEAPPDYL-LEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPSR 213
            |......| ..::||:||.|||||.:||.||..:...||.|.||...||.:|:..|..|||:|..
  Rat   150 STYDGQVLSAHENVVVVTIQYRLGIWGFFSTGDEHSQGNWGHLDQVAALHWVQDNIANFGGNPGS 214

  Fly   214 VTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCKMVTV 278
            ||:.|:..|......|.|||:. :.|||:.|..||..:....:..|.:..|..||..:.||..|.
  Rat   215 VTIFGESAGGFSVSALVLSPLA-KNLFHRAISESGVVLTSALITTDSKPIANLIATLSGCKTTTS 278

  Fly   279 RDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSG------------VLPKHPY 331
            ..:..||.:.|..|||...::..|.|.||           :|.|..            ||||.|.
  Rat   279 AVMVHCLRQKTEDELLETSLKLNLFKLDL-----------LGNPKESYPFLPTVIDGVVLPKTPE 332

  Fly   332 DLMLETNF-SYPAMGGCPKNAGSRVLNEIVDNDF-EGKIPDDEYNTYNYIDHVIRQTVGTDKTML 394
            :::.|.:| :.|.:.|..|.....::..::.... |||:...                 |.|::|
  Rat   333 EILTEKSFNTVPYIVGINKQEFGWIIPTLMGYPLSEGKLDQK-----------------TAKSLL 380

  Fly   395 LTSF------------VTHDFFNRNLMENGTFDTLIPRLI--DVAGTLNHKLP-VLLALNMNNKH 444
            ..|:            |...:|      .||.|....:.:  |:...:...:| |:::.:..:..
  Rat   381 WKSYPTLKISEKMIPVVAEKYF------GGTDDPAKRKDLFQDLVADVMFGVPSVMVSRSHRDAG 439

  Fly   445 NPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLSRPDQSMAHR 509
            .|  ||:|.|:|...|         .:...|........||...:|..|......|..:.:::..
  Rat   440 AP--TFMYEFEYRPSF---------VSAMRPKTVIGDHGDELFSVFGSPFLKDGASEEETNLSKM 493

  Fly   510 MVELWTNFVISGNPLGSARVGYWPPMTTLYGPYMRIDDTMTIGGNYFTEFSATLSDEE 567
            :::.|.||..:|:|.|.. :.:||       .|.:.:..:.||.:  |:.:..|.|:|
  Rat   494 VMKYWANFARNGSPNGGG-LPHWP-------EYDQKEGYLKIGAS--TQAAQRLKDKE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	151/567 (27%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	155/578 (27%)
		Aes	<121..>239	CDD:223730	49/118 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850