DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and Ces1f

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	167/582 - (28%)
Similarity:	253/582 - (43%)	Gaps:	123/582 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSM 104
            |.|.:.||.:......:.|..|:.|.:|:||.|..||..|:|.|||..|.:.|.    .|.:.|.
  Rat    29 TKGKVLGKYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTT----YPPMCSQ 89

  Fly   105 DSLR--RLDDVLD----------VEDCLTMTITTP---NVTSRLPVLVYIHGEYL-------YEG 147
            |:.:  |::|:|.          .||||.:.|.||   ...|||||:|:|||..:       |:|
  Rat    90 DAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVWIHGGGMTLGGASTYDG 154

  Fly   148 SNSEAPPDYLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPS 212
            ....|      .::||:|..|||||.:||.||..:...||.|.||...||.:|:..|..|||||.
  Rat   155 RVLSA------YENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPG 213

  Fly   213 RVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCKMVT 277
            .||:.|:..|.....:|.|||:. :.|||:.|..||...:|..|.:|.|..|::||..|.|:..|
  Rat   214 SVTIFGESAGGFSVSVLVLSPLT-KNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGCETTT 277

  Fly   278 VRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQF--TIGGPSGVLPKHPYDLMLETNF- 339
            ...:..||.:.|..|||....:..|.|......:.....|  |: ..:.||||.|.:::.|.||
  Rat   278 SAIIVHCLRQKTEEELLEIMKKMNLIKLSSQRDNKESYHFLSTV-VDNVVLPKDPKEILAEKNFN 341

  Fly   340 SYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFF 404
            :.|.:.|..|.....:|..::     |.:|.|               |..||.|.:|
  Rat   342 TVPYIVGINKQECGWLLPTMM-----GFVPAD---------------VELDKKMAIT-------- 378

  Fly   405 NRNLMEN-----GTFDTLIPRLID------------------VAGTLNHKLP-VLLALNMNNKHN 445
               |:|.     |..:.:||..|:                  ..|.::..:| |:::.:..:...
  Rat   379 ---LLEKFASLYGIPEDIIPVAIEKYRKGSDDSIKIRDGILAFIGDVSFSIPSVMVSRDHRDAGA 440

  Fly   446 PDNTFLYSFDYAGEFN---RYKEM--DEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLSRPDQS 505
            |  |::|.:.|...|:   |.|.:  |...:|.|.|.|.: |.|.|             |..:..
  Rat   441 P--TYMYEYQYYPSFSSPQRPKHVVGDHADDLYSVFGAPI-LRDGA-------------SEEEIK 489

  Fly   506 MAHRMVELWTNFVISGNPLGSARVGYWPPMTTLYGPYMRIDDTMTIGGNYFTEFSATLSDEE 567
            ::..:::.|.||..:|||.|.. :.:||       .|.:.::.:.||..  |:.|..|..||
  Rat   490 LSKMVMKFWANFARNGNPNGRG-LPHWP-------QYDQKEEYLQIGAT--TQQSQRLKAEE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	162/571 (28%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	167/582 (29%)
		Aes	<121..>234	CDD:223730	47/118 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750