DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ache

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_038945765.1	Gene:	Ache / 83817	RGDID:	69313	Length:	616	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	169/602 - (28%)
Similarity:	244/602 - (40%)	Gaps:	116/602 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQP-IGYQGRVNATVQSPNCAQ-----F 126
            ||:.||  .......||:|||||.:.....|..||...:| ..:.|.::||.....|.|     :
  Rat    46 GQLRGI--RLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLY 108

  Fly   127 PELDRLRLSESRGENVDDCLTLDIYA--PEGANQLPVLVFVHGEMLFDGGSEEAQPD--YVLE-K 186
            |..:...:.....|..:|||.|:::.  |...:..|||::::|...:.|.|.....|  ::.: :
  Rat   109 PGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVE 173

  Fly   187 DVLLVSINYRLAPFGFLSAL--TDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGA 249
            ..:|||:|||:..|||| ||  :.:.||||.|.|.:|||:|:|.|:..|||:...|||.|::.||
  Rat   174 GTVLVSMNYRVGTFGFL-ALPGSRDAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGA 237

  Fly   250 TLA--HALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLST---------FARLARCPPPSI 303
            ...  |.|||..|  :||.:.:|||||       .|.|..|:|.         .|||..|||...
  Rat   238 ASVGMHILSLPSR--SLFHRAVLQSGT-------PNGPWATVSAGEARRRATLLARLVGCPPGGA 293

  Fly   304 NPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLA-T 367
            ..:.   ..|..||...|...||.....:|.|.   .:.:.....:|.||   ||...|.:|. |
  Rat   294 GGND---TELISCLRTRPAQDLVDHEWHVLPQE---SIFRFSFVPVVDGD---FLSDTPEALINT 349

  Fly   368 NSSLALPMIIGATKD-ASAFIV------SRIYDQL---------ARLQSRNVSDYI--DVVLRHT 414
            .....|.:::|..|| .|.|:|      |:..:.|         .|:.....||..  .|||.:|
  Rat   350 GDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYT 414

  Fly   415 APPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYT 479
                      .|     ..|  |..|.|:.....::...|.:...|.:...::.....|.||::
  Rat   415 ----------DW-----LHP--EDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIF- 461

  Fly   480 FDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPL--DRSLSRALVTMWVNFATT 542
                  .||...|:.||..||......:.::..|..|.   ||..  :|..::.|:..|.|||.|
  Rat   462 ------EHRASTLTWPLWMGVPHGYEIEFIFGLPLDPS---LNYTVEERIFAQRLMKYWTNFART 517

  Fly   543 GVPN----PSSGVWPQATSEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRVIYKPT----TNFS 599
            |.||    ..|..||..|:        ...|...|.|.|       |...|.:...|    ..|.
  Rat   518 GDPNDPRDSKSPRWPPYTT--------AAQQYVSLNLKP-------LEVRRGLRAQTCAFWNRFL 567

  Fly   600 PPITTTTTTTTTTTTTS 616
            |.:.:.|.|....|..|
  Rat   568 PKLLSATATEVPCTCPS 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	160/559 (29%)
		Aes	<146..345	CDD:223730	73/216 (34%)
		RILP-like	<677..>717	CDD:304877
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	163/579 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910