DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2g

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_932116.2	Gene:	Ces2g / 72361	MGIID:	1919611	Length:	560	Species:	Mus musculus

Alignment Length:	558	Identity:	153/558 - (27%)
Similarity:	241/558 - (43%)	Gaps:	91/558 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVNATV 118
            |:.:.:::...||:.|...|.......|:.||||.:.....|..||   :|.:|  :.|..:.|.
Mouse    30 PETSPIRSTHSGQVQGRLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEP--WSGVRDGTS 92

  Fly   119 QSPNCAQ-----FPELDRLRLSESRGENVDDCLTLDIYAP----EGANQLPVLVFVHGEML---- 170
            |...|.|     ...|..|:|:.......:|||.|:||.|    ||:| |||:|::||..|
Mouse    93 QPAICPQNVTMNMEGLKELKLTLPPVSMSEDCLYLNIYTPAHAQEGSN-LPVMVWIHGGALTVGM 156

  Fly   171 ---FDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVH 232
               :||....|      .:||::|:|.|||...||.|...:...||....|...||.|:|:|:.|
Mouse   157 ASMYDGSVLAA------TEDVVVVAIQYRLGVLGFFSTGDEHARGNWGFLDQVAALRWVQQNIAH 215

  Fly   233 FGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLAR 297
            ||||..:||:.|::.|.....:..:|..:..||.:.|::||.||.|..|.:.......|.|:|:.
Mouse   216 FGGNPDRVTIFGESAGGISVSSHVVSPMSKGLFHRAIMESGVALLPGTIFSFSEVVYQTVAKLSG 280

  Fly   298 CPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG-FLPSH 361
            |       .|...:.|..||......:::|..:               .|:::.|...| |||.|
Mouse   281 C-------EAMDSEALVRCLRGKSEEEILAISK---------------NFQMIPGVVDGEFLPKH 323

  Fly   362 PASLATNSSL-ALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTA-----PPSEH 420
            |..|..::.. .:|.|||...|...:||.::......::. ...:.:..||:.||     ||...
Mouse   324 PQELLASADFHPVPSIIGFNNDEYGWIVPKVIGSTQTIKG-ITRENLQAVLKDTAPQMMLPPECS 387

  Fly   421 RLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSY--RS-VPAYLYTFDY 482
            .|..:..:.:|..|   :|..:|     ..|:....::   ||.|:..:|  || .|.|.|.|
Mouse   388 DLLMEEYMEDIEDP---KTLQIQ-----FTEMMEDFMF---VIPSLQVAYFQRSHAPVYFYEF-- 439

  Fly   483 RGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLN--PLDRSLSRALVTMWVNFATTGVP 545
               .|:...|.:..|..|:|...|:..::|.......:||  ..::.|:|.::..|.|||..|.|
Mouse   440 ---QHQSSFLKDVRPPHVNADHGDEVPFVFGSFFWGMKLNLTEEEKLLNRRMMKYWANFARHGNP 501

  Fly   546 NPSS-GVWPQATSEYGPFLRFTNNQQ-SPLELDPHFGE 581
            |..| ..||.          |.:::| ..|.:.|..|:
Mouse   502 NSESLPYWPV----------FDHDEQYLQLNIQPAVGQ 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	152/554 (27%)
		Aes	<146..345	CDD:223730	64/209 (31%)
		RILP-like	<677..>717	CDD:304877
Ces2g	NP_932116.2	COesterase	31..539	CDD:278561	152/557 (27%)
Ces2g	NP_932116.2	Aes	72..>337	CDD:223730	87/295 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840