DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and TG

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	604	Identity:	149/604 - (24%)
Similarity:	232/604 - (38%)	Gaps:	148/604 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YAQP------QEAVVQAPEV---GQILGISGHKTIAN--RPVNAFLGIRYGTVGGGLARFQAAQP 107
            |.:|      .||.|.:..:   |::||.|....:..  :.|:.|||:.|........||||.:|
Human  2184 YRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEP 2248

  Fly   108 IGYQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPEG-ANQLPVLVFVHGEMLF 171
            :.:.|..:|:....:|.|    ...|.|.|.|.: :|||.|:::.|:. |....||||.|..|
Human  2249 LNWTGSWDASKPRASCWQ----PGTRTSTSPGVS-EDCLYLNVFIPQNVAPNASVLVFFHNTM-- 2306

  Fly   172 DGGSEEAQPD-----YVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVV 231
            |....|..|.     .....::::|:.:||:..|||||:.:.|:.||..|.|...||.|:|.::.
Human  2307 DREESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIR 2371

  Fly   232 HFGGNAGQVTLVGQAGGATLAHALSLSGRAGN--LFQQLILQSGTALNPYLI--DNQPLDTLSTF 292
            .|||:..:|:|....|||.:|....|:.||.|  ||::.:|..|:||:|..:  ..:........
Human  2372 GFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIAL 2436

  Fly   293 ARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPL-- 355
            |:...||..|       .:.:..||.:.|.:.|..|..:|                |.|..|.
Human  2437 AKEVSCPMSS-------SQEVVSCLRQKPANVLNDAQTKL----------------LAVSGPFHY 2478

  Fly   356 ------GFLPSHPASLATNSSL--ALPMIIGATKD---------ASAFIVSR--------IYDQL 395
                  |.....|.:.|...||  .:.::||:::|         ...|..||        .|..|
Human  2479 WGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQAL 2543

  Fly   396 ----------ARLQSRNVSDYIDVVLRHTAP--PSEHRLWKQWALREIF--TPIQEQTASLQTVA 446
                      ||:::.....|   .|.|:..  .|..|..:. |.|:.|  .||.:..::....|
Human  2544 QNSLGGEDSDARVEAAATWYY---SLEHSTDDYASFSRALEN-ATRDYFIICPIIDMASAWAKRA 2604

  Fly   447 PGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYL 511
            .|     |..:|.||                         ..:||.|..|...|..:|.
Human  2605 RG-----NVFMYHAP-------------------------ENYGHGSLELLADVQFALG------ 2633

  Fly   512 FP-YPPEASRLNPLDRSLSRALVTMWVNFATTGVPN--------------PSSGVWPQATSE-YG 560
            .| ||....:.:..::|||..::..:.:|..:|.||              |.....|:|..| |.
Human  2634 LPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYK 2698

  Fly   561 PFLRFTNNQQSPLELDPHF 579
            .|.....|:|...:.|..|
Human  2699 EFSELLPNRQGLKKADCSF 2717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	147/601 (24%)
		Aes	<146..345	CDD:223730	60/208 (29%)
		RILP-like	<677..>717	CDD:304877
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187		1/2 (50%)
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		147/600 (25%)
		COesterase	2197..2718	CDD:395084	145/591 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930