DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2j

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	158/563 - (28%)
Similarity:	227/563 - (40%)	Gaps:	82/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PDYNDYSDEDTRRDWLPEPLKPVPWQS----ETRYAQPQEAVVQAPEVGQILGISGHKTIANRPV 84
            |...|..::..||:  .|..|.:|..:    .|...|...:.::....||:.|...|.......:
  Rat    13 PPTLDSREKGLRRE--RERKKGIPDSNLHSFLTEQGQDSASPIRNTHTGQVRGSFVHVKDTKSGI 75

  Fly    85 NAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNCAQF----------PELDRLRLSESR 138
            :.||||.:.....|..||...: |..:.|..:||.|...|.|.          .||.:|.:||
  Rat    76 HTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTAMMNLEGMKETELTKLPMSE-- 138

  Fly   139 GENVDDCLTLDIYAPEGANQ---LPVLVFVHGEMLFDGGSEEAQPDYVL--EKDVLLVSINYRLA 198
                 |||.|:||.|..|::   |||:|::||..|. |||........|  .:::::|||.|||.
  Rat   139 -----DCLYLNIYVPAHAHEDSNLPVMVWIHGGGLV-GGSASMNDASTLAATEEIVIVSIQYRLG 197

  Fly   199 PFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGN 263
            ..||.|.......||....|...||.|:|:|:.:||||...||:.|.:.|.|...:..:|..:..
  Rat   198 VLGFFSTGDQHARGNWGYLDQMAALRWVQQNIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMSKG 262

  Fly   264 LFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAA 328
            ||.:.|:|||.||.|.||.:.......|.|.|:.|       .|...:.|..|| |..:.|.:.|
  Rat   263 LFHRAIMQSGVALLPGLISDTSEVVYKTVANLSGC-------EASDSEALIRCL-RAKSKQEILA 319

  Fly   329 FEQLLLQNEHLGLTQLGGFKLVVGDPLG-FLPSHPAS-LATNSSLALPMIIGATKDASAFIVSRI 391
            ..|:              ||::.|...| |||.||.. ||:.....:|.|||...|...:.|..|
  Rat   320 INQV--------------FKMIPGVVDGKFLPKHPQELLASKDFHPVPSIIGVNTDECGWGVPTI 370

  Fly   392 YDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWAL-REIFTPIQEQ----TASLQTVAPGLLE 451
            .         .:...|:.:.|.|.|.:......|..| .|....|.|:    |...:|:.....|
  Rat   371 L---------GLYHIINNITRETLPAALKIAAAQMMLPPECIDLIMEEYMGDTEDAETLQAQFKE 426

  Fly   452 LSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFP--Y 514
            :....::..|.:..........|.|.|.|     .|....:....||...|...||:|::|.  :
  Rat   427 MLGDFIFVIPALQVAHFQRSQAPVYFYEF-----QHLLSFIKQVRPFYPKADHGDDTVFVFGSYF 486

  Fly   515 PPEASRLNPLDRSLSRALVTMWVNFATTGVPN----PSSGVWP 553
            ......|...:..|.|.::..|.|||.||.||    |.   ||
  Rat   487 WGMTFDLTEEEELLKRRVMKYWANFARTGNPNGEDLPH---WP 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	150/528 (28%)
		Aes	<146..345	CDD:223730	67/203 (33%)
		RILP-like	<677..>717	CDD:304877
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	149/524 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840