DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and Ces1a

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	150/542 - (27%)
Similarity:	229/542 - (42%)	Gaps:	92/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQS 120
            |....:|...:|:.:.:.|.    .:||..|||:.:.....|..||...||......| |||...
  Rat    24 PVVDTLQGKVLGKYISLEGF----TQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVKNATSYP 84

  Fly   121 PNCAQFPELDRLRLSE---SRGENV-----DDCLTLDIYAP---EGANQLPVLVFVHGEMLFDGG 174
            |.|:|...:..: |||   ::.|||     :|||.|:||:|   ...::|||:|:|||..|..||
  Rat    85 PMCSQITGVGPV-LSEVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGG 148

  Fly   175 SE--EAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNA 237
            :.  :.......|| |::|.|.|||..:||||...:...||....|...||:|:|.|:|:|||:.
  Rat   149 ASTFDGLALSTHEK-VVVVVIQYRLGIWGFLSTGDEHSRGNWGHFDQVAALQWVQNNIVNFGGDP 212

  Fly   238 GQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPS 302
            ..|||.|::.|......|.||....|||.:.|.:||.||.|.|............|....|
  Rat   213 NSVTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLFRENTRLAAEQVAIATGC---- 273

  Fly   303 INPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGG------FKLVVGDPLGFLPSH 361
               :|.....:..||......:|:|.    .|:.:...|...|.      |...|.|.: .||..
  Rat   274 ---AATTSADIVRCLREKTEEELLAT----TLKMKFFALDLHGDPRESYPFLTTVIDGV-LLPKA 330

  Fly   362 PASLATNSSL-ALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHR---- 421
            |..:.:..:. .:|.|:|..|....:                   :|..::.:  |.||.:
  Rat   331 PEEILSEKNFNTVPYIVGINKQEFGW-------------------FIPTMMGY--PLSESKLDQK 374

  Fly   422 -----LWKQWALREI---FTPIQEQTASLQTVAPG-----LLELSNYILYRAPVINSISQSYRSV 473
                 |||.:.|..|   .||:..:.....:..|.     .|::...:|:..|.: .:::.:|..
  Rat   375 TATSLLWKSYPLTNISKELTPVATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPSV-IVARYHRDA 438

  Fly   474 PA--YLYTFDYRGEHHRFGHLSNPLPFGVDASLSDD--SVYLFPYPPEASRLNPLDRSLSRALVT 534
            .|  |:|.|.|   |..|  :|:..|..|.|...|:  ||:..|:..|.:....:  :||..::.
  Rat   439 RATTYVYEFKY---HPSF--VSDMRPKTVIADHGDEVYSVWGTPFLKEGASEEEI--NLSTMMMK 496

  Fly   535 MWVNFATTGVPNPSSGV--WPQ 554
            .|.|||..|.|| ..|:  ||:
  Rat   497 FWGNFARNGNPN-GEGLPHWPE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	150/542 (28%)
		Aes	<146..345	CDD:223730	66/203 (33%)
		RILP-like	<677..>717	CDD:304877
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	150/542 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336504
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850