DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and NLGN2

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	910	Identity:	216/910 - (23%)
Similarity:	302/910 - (33%)	Gaps:	317/910 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNCAQ--- 125
            |::.|:  .:.:.|.   ||..|||:.|.|...|..|||..: |..:.|..|||...|.|.|
Human    49 GRVRGV--RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLH 111

  Fly   126 --FPEL-------DRLRLSESRGEN-VDDCLTLDIYAPEGANQL--------------------- 159
              .|.:       |.|..:.:..:| .:|||.|::|.|.....|
Human   112 GALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGK 176

  Fly   160 -PVLVFVHGEM-------LFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVAL 216
             ||::|:||..       :|||....|.      .:|::.::||||...||||.......||..|
Human   177 KPVMLFLHGGSYMEGTGNMFDGSVLAAY------GNVIVATLNYRLGVLGFLSTGDQAAKGNYGL 235

  Fly   217 SDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI 281
            .|...||.||..|:.||||:..::|:.|...||:..:.|.||..:..|||:.|.|||||::.:.:
Human   236 LDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV 300

  Fly   282 DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLV----------AAF------- 329
            :.|||......|....|   ....||:.:    :||.|.|:.:||          .||
Human   301 NYQPLKYTRLLAAKVGC---DREDSAEAV----ECLRRKPSRELVDQDVQPARYHIAFGPVVDGD 358

  Fly   330 ------EQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIGATKDASAFIV 388
                  |.|:.|.|.|....|.|..  .|:.|.|:.....|..           |.:..|..|.|
Human   359 VVPDDPEILMQQGEFLNYDMLIGVN--QGEGLKFVEDSAESED-----------GVSASAFDFTV 410

  Fly   389 SRIYDQLARLQSRNVSDYID--VVLRHTAPPSEHRLWKQWALRE-----------IFTPIQEQTA 440
            |...|        |:..|.:  .|||.|.    ..::..||.|:           :||
Human   411 SNFVD--------NLYGYPEGKDVLRETI----KFMYTDWADRDNGEMRRKTLLALFT------- 456

  Fly   441 SLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLS 505
            ..|.|||.:.....:..|::||             |.|||    .||   ..:...|...||:..
Human   457 DHQWVAPAVATAKLHADYQSPV-------------YFYTF----YHH---CQAEGRPEWADAAHG 501

  Fly   506 DDSVYLFPYP-PEASRLNPL-----DRSLSRALVTMWVNFATTGVPNPSSGVWPQATS------- 557
            |:..|:|..| ..|:.|.|.     |..||..::|.|.|||.||.||...   ||.|.
Human   502 DELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV---PQDTKFIHTKPN 563

  Fly   558 --EYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRVIYKPT-----TNFSPPITTTTTTTTTTTTT 615
              |...:.:|.:.::..|    |.|   ..|..|..|:..     ....|.:....|...||||.
Human   564 RFEEVVWSKFNSKEKQYL----HIG---LKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTR 621

  Fly   616 SRPYAYNPYANWQNRPSQQHPNWHPADPEYVRAQEARQQEFIREREQRRREQQLRDQQRYPQQEP 680
            ..|||    ..|..||....|......|......|                         |:.||
Human   622 LPPYA----TRWPPRPPAGAPGTRRPPPPATLPPE-------------------------PEPEP 657

  Fly   681 REQQDERI-RQQREQEERL-----------------------RQQREQEERLRQ----------- 710
            ..:..:|. ...|:....|                       ::.|.||.|.|:
Human   658 GPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGV 722

  Fly   711 ----------QRELEERIRQQQEREQYEREQQEREQREREELERQQRER---------EQQQPEQ 756
                      .|||.                      ..|||...|.:|         |..:|..
Human   723 PGGGPLLPAAGRELP----------------------PEEELVSLQLKRGGGVGADPAEALRPAC 765

  Fly   757 QPEYN--------------------------------PEPVNPWGYPVQEPQPDDNPEDGRLPYP 789
            .|:|.                                |..::|:| |...|.|.....:..||:|
Human   766 PPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFG-PFPPPPPTATSHNNTLPHP 829

Fly 790 789
Human 830 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	164/607 (27%)
		Aes	<146..345	CDD:223730	72/250 (29%)
		RILP-like	<677..>717	CDD:304877	13/84 (15%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	169/628 (27%)
		Aes	<170..>268	CDD:223730	33/103 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668		13/73 (18%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835		9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840