DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and ces3

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001038401.1	Gene:	ces3 / 560651	ZFINID:	ZDB-GENE-030131-9563	Length:	549	Species:	Danio rerio

Alignment Length:	565	Identity:	140/565 - (24%)
Similarity:	218/565 - (38%)	Gaps:	124/565 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPI-GYQGRVNATVQSPNCAQFP---- 127
            ||.:...|...:    |..:|||.:.....|..|..|.||: |::|..|||..|..|.|.|
Zfish    38 GQYVKAKGSPAV----VEQYLGIPFAQPPVGPHRLAAPQPVQGWEGIRNATEYSSMCLQDPNIVP 98

  Fly   128 --------ELDRLRLSESRGENVDDCLTLDIYAP---EGANQLPVLVFVHGEMLFDGGS--EEAQ 179
                    ||....:||       |||.|::|.|   ..:::.||:|::||..|..||:  .:..
Zfish    99 KYAKSMTLELPPTGVSE-------DCLYLNVYTPSQRSESDKFPVMVWIHGGALVIGGACMYDGT 156

  Fly   180 PDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVG 244
            |....|| |::|.|.|||...|:||.......||....|...||:|:|:|:..|||:...||:.|
Zfish   157 PLAAYEK-VVVVVIQYRLGILGYLSTGDQHAQGNWGFLDQIAALQWVQQNIEAFGGDPQSVTIAG 220

  Fly   245 QAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQG 309
            ::.|...|..|:||.....|||:.|.|||.|.........||......|.:..|       ....
Zfish   221 ESAGGISASLLTLSPMTKGLFQRAIFQSGVATVKGYSFKDPLTYAKVIANITEC-------DFSS 278

  Fly   310 LKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSL-AL 373
            .:.|..|:..:...|::.|.::..         :|.| ..|.|:   |:.:.|..:..:... .:
Zfish   279 SEVLVKCIREMTEEQIIKAAQKKY---------RLPG-ATVDGE---FIKAQPEEILKSKDFPKI 330

  Fly   374 PMIIGATKDASAFIVSRIY---DQLARLQSRNVSDYIDV----------------VLRHTAPPSE 419
            |:::|.|.....:.:|...   |....:.:::....:|.                ..::...|.|
Zfish   331 PILVGTTNHEFGWTLSHAILPKDWAKGMDAKSAKQTLDFFYNAGASEANGIIADEYFKNAKTPEE 395

  Fly   420 HRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSIS-QSYR---SVPAYLYTF 480
                    :|:.||.:                |.:.|:    ||.||. .||.   ..|.|:|.|
Zfish   396 --------IRDAFTEL----------------LGDIIM----VIPSIKVASYHRDAGAPVYMYEF 432

  Fly   481 DYRGEHHRFGHLSNPL-PFGVDASLSDDSVYLF------PYPPEASRLNPLDRSLSRALVTMWVN 538
            .:...      ::|.. |..|.|...|:..::|      ........|...:..|.|.::..|.|
Zfish   433 QHGPS------IANKFRPSFVKADHGDEIGFMFGACFWDGQVKVTGTLTEEENQLCRTVMKYWAN 491

  Fly   539 FATTGVPNPSSGVWPQATSEYGPFLRFTNNQQSPLELDPHFGEGI 583
            |..||.|||:...||    .|....::.|     |.|....|:|:
Zfish   492 FVRTGSPNPAPVPWP----VYDQSNKYLN-----LGLQQTEGQGL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	138/559 (25%)
		Aes	<146..345	CDD:223730	59/203 (29%)
		RILP-like	<677..>717	CDD:304877
ces3	NP_001038401.1	COesterase	24..535	CDD:278561	140/565 (25%)
ces3	NP_001038401.1	Aes	<122..>235	CDD:223730	40/113 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840