DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2h

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	152/565 - (26%)
Similarity:	234/565 - (41%)	Gaps:	96/565 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QPQEAV--VQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVN 115
            |.|:::  ::....|||||...|....:..|::||||.:.....|..||   :|.:|  :.|..:
  Rat    24 QGQDSLSPIRTTHTGQILGSLIHMKGLDVGVHSFLGIPFAKPPIGPLRFAPPEAPEP--WSGVRD 86

  Fly   116 ATVQSPNCAQ------FPELDRLRLSESRGENVDDCLTLDIYAP----EGANQLPVLVFVHG--- 167
            .|.....|.|      ......|:|:.......:|||.|:||.|    ||:| |||:|::||
  Rat    87 GTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSEDCLYLNIYTPNHAHEGSN-LPVMVWIHGGAL 150

  Fly   168 ----EMLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQR 228
                ..|:||....|.      ::|::|:|.|||...||.|.......||....|...||.|:|:
  Rat   151 VIGMASLYDGSMLAAM------ENVVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQVAALHWVQQ 209

  Fly   229 NVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFA 293
            |:.|||||..:||:.|::.|.|...:..:|..:..||...|::||.||...||.........|.|
  Rat   210 NIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSRGLFHGAIMESGVALMSSLISVSSDVVYRTVA 274

  Fly   294 RLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG-F 357
            .|:.|       .....|.|.:||..       .:.|:::..|:        .|:::.|...| |
  Rat   275 NLSGC-------EQVDSKALVNCLRG-------KSEEEIMSINK--------AFRIISGIVDGIF 317

  Fly   358 LPSHPASLATNSSL-ALPMIIGATKDASAFIVSRIYDQLARLQSRNVSD--YIDVVLRHTA---- 415
            ||.||..|..::.. .:|.|||...|...:|:.   ..:....|:...|  .:..:|:...
  Rat   318 LPRHPKELLASADFHPIPSIIGVNNDEYGWIIP---SSMTTTDSKKKMDRQMVQAILQKRVAQMM 379

  Fly   416 -PPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYT 479
             ||....|     |.|.:....|....||.....::|...:::   |.:........:.|.|.|.
  Rat   380 WPPEFSDL-----LLEEYMGDSEDPQFLQVQFKEMMEDFTFVI---PALQVAHFQRSNAPVYFYE 436

  Fly   480 FDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFP--YPPEASRLNPLDRSLSRALVTMWVNFATT 542
            |     .||.....:..|..|.|...|:.:::|.  :......|...:..|||.::..|.|||..
  Rat   437 F-----QHRPSFFKDSKPPHVKADHGDEILFIFRSFWGGTQVDLTEEEELLSRRMMKYWANFARQ 496

  Fly   543 GVPNPSSGV--WPQATSEYGPFLRFTNNQQSPLELD--PHFGEGI 583
            |.|| |.|:  ||.          |.:::|. |:||  |..|..:
  Rat   497 GNPN-SEGLPYWPV----------FDHDEQY-LQLDTQPAVGRAL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	151/559 (27%)
		Aes	<146..345	CDD:223730	65/209 (31%)
		RILP-like	<677..>717	CDD:304877
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	150/559 (27%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	41/109 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840