DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and COEBE3D

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_556011.2	Gene:	COEBE3D / 4576532	VectorBaseID:	AGAP005372	Length:	564	Species:	Anopheles gambiae

Alignment Length:	550	Identity:	151/550 - (27%)
Similarity:	239/550 - (43%)	Gaps:	91/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 AFLGIRYGTVGGGLARFQA--------AQPIGYQGRVNATVQSPNCAQFPELDRLRLSESRGENV 142
            ||.||.|.....|..||.|        .:|      .|||.:.|.|.|:   :.|....::.|..
Mosquito    45 AFEGIPYAKPPLGKLRFAAPELNDDRWTEP------RNATERGPVCLQW---NHLIPGHNKLEGT 100

  Fly   143 DDCLTLDIY--APEGANQLPVLVFVHGEMLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSA 205
            :|||.|::|  :.:...:||.:.|:||..|..|.....:||:::.:.::||:.||||.|.||||.
Mosquito   101 EDCLFLNVYTRSIDPTARLPTIAFIHGGALMFGTGNFYEPDHIMRRQMILVTFNYRLGPLGFLST 165

  Fly   206 LTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLIL 270
            ..|.:|||..|.|..:||:|::.|:..|||:...|::||.:.|:...|...||..:..||...|.
Mosquito   166 EDDVIPGNFGLKDQVIALQWIRENIESFGGDPETVSIVGYSAGSASVHLHYLSPLSRGLFTSGIG 230

  Fly   271 QSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQ 335
            .||:||||:::..:.::.......:..||       .:..:.|.|||.:.|...:|....|.|
Mosquito   231 HSGSALNPWVMMERSVEKAIRIGAVLGCP-------TRKTQALLDCLRKQPAEDIVRQVPQFL-- 286

  Fly   336 NEHLGLTQLGGFKLVVG-----DPLGFLPSHPASLATNSSLA-LPMIIGATK-----DASAFIVS 389
             ::| ......|..||.     :|..||...|.||.::.::| :|:|:..|:     ..:.||..
Mosquito   287 -DYL-YNPFSPFGAVVEKKGPLNPHPFLQETPRSLMSSGNIAKVPLILSVTEAEGLYPGAEFISD 349

  Fly   390 RIYDQLARLQSR------NVSDYIDVVLRHTAPPSEHRLWKQWALR-EIFTPIQEQTASLQTVAP 447
            ..|  |..:.:|      ::.||...|   ..|.:..||.:  |:| ..|.|  .:..||:....
Mosquito   350 PKY--LQEIDARWDELVPSILDYKTSV---PDPKARDRLSE--AIRNHYFGP--NERLSLENFKT 405

  Fly   448 GLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFG------HLSNPLPFGVDASLSD 506
            .:..:||. ||.|.|..|....:.....|:|...|:.   :||      |...|...||  :..|
Mosquito   406 LIRIISNR-LYFAGVTESAKLMHPFTNVYVYYDLYKS---KFGVGEALSHRDEPGLLGV--AHGD 464

  Fly   507 DSVYLFP------YPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGVWP-QATSEYGPFLR 564
            |.:.:||      .|.....:..:||     .|||:.:||....|...:...| |.:::...||.
Mosquito   465 DVLLIFPSVLREEVPFTEEEMQVVDR-----FVTMYEHFAKGDQPRFGAYELPLQDSTDKLVFLE 524

  Fly   565 FTNNQQSPLEL-----DPH-----FGEGIY 584
            ....|...:..     :|:     |.:|.|
Mosquito   525 LNYPQSKTVRAEGVSDEPYWKTLDFNDGPY 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	148/543 (27%)
		Aes	<146..345	CDD:223730	63/200 (32%)
		RILP-like	<677..>717	CDD:304877
COEBE3D	XP_556011.2	Abhydrolase	27..504	CDD:304388	141/498 (28%)
COEBE3D	XP_556011.2	Aes	<108..>208	CDD:223730	37/99 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920