DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and ACHE

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	528	Identity:	151/528 - (28%)
Similarity:	221/528 - (41%)	Gaps:	103/528 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVNATVQSPNCAQ-----FPELDRLRLSESRG 139
            ||:|||||.:.....|..||   :..||  :.|.|:||.....|.|     :|..:...:.....
Human   126 PVSAFLGIPFAEPPMGPRRFLPPEPKQP--WSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNR 188

  Fly   140 ENVDDCLTLDIYA--PEGANQLPVLVFVHGEMLFDGGSEEAQPD---YVLEKDVLLVSINYRLAP 199
            |..:|||.|:::.  |...:..||||:::|...:.|.|.....|   .|..:..:|||:|||:..
Human   189 ELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGA 253

  Fly   200 FGFLSAL--TDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAG 262
            |||| ||  :.|.||||.|.|.:|||:|:|.||..|||:...|||.|::.||.......||..:.
Human   254 FGFL-ALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 317

  Fly   263 NLFQQLILQSGTALNPYLIDNQPLDTL---------STFARLARCPPPSINPSAQGLKPLYDCLA 318
            .||.:.:||||.       .|.|..|:         :..|.|..|||.....:.   ..|..||.
Human   318 GLFHRAVLQSGA-------PNGPWATVGMGEARRRATQLAHLVGCPPGGTGGND---TELVACLR 372

  Fly   319 RLPTSQLVAAFEQLLLQNEHLGLTQLGGFK-----LVVGDPLGFLPSHPASLATNSSL-ALPMII 377
            ..|.        |:|:.:|...|.|...|:     :|.||   ||...|.:|...... .|.:::
Human   373 TRPA--------QVLVNHEWHVLPQESVFRFSFVPVVDGD---FLSDTPEALINAGDFHGLQVLV 426

  Fly   378 GATKDASAF---------------IVSRIYDQLA--RLQSRNVSDYI--DVVLRHTAPPSEHRLW 423
            |..||..::               ::||. :.||  |:....|||..  .|||.:|
Human   427 GVVKDEGSYFLVYGAPGFSKDNESLISRA-EFLAGVRVGVPQVSDLAAEAVVLHYT--------- 481

  Fly   424 KQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHR 488
             .|     ..|  |..|.|:.....::...|.:...|.:...::.....|.||::       .||
Human   482 -DW-----LHP--EDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVF-------EHR 531

  Fly   489 FGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPN----PSS 549
            ...||.||..||......:.::..|..| :......::..::.|:..|.|||.||.||    |.:
Human   532 ASTLSWPLWMGVPHGYEIEFIFGIPLDP-SRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKA 595

  Fly   550 GVWPQATS 557
            ..||..|:
Human   596 PQWPPYTA 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	151/528 (29%)
		Aes	<146..345	CDD:223730	72/214 (34%)
		RILP-like	<677..>717	CDD:304877
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	151/528 (29%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142761
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840