DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and CG10175

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	163/569 - (28%)
Similarity:	261/569 - (45%)	Gaps:	104/569 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QSETRYAQPQEAVVQAPEVGQILG-ISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQP-IGYQ 111
            |...|..:.:..:|....:|::.| ...:::.......:|.|:|||....|..||:||:| ..:.
  Fly   142 QEVVRSLRKEREIVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWS 206

  Fly   112 GRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYA------PEGANQ--LPVLVFVHGE 168
            |..:|:.:..:|   |..:.: |...:|:  :|||.::::.      .|.|.|  |||:|::||.
  Fly   207 GIRDASREGQSC---PHKNMI-LDTFKGD--EDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGG 265

  Fly   169 MLFDGGSEEA---QPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNV 230
            . |..||..:   .|||::.:|::||::||||.|.|||:|..| .|||..|.|..|||:|::.|:
  Fly   266 G-FSFGSGNSFLYGPDYLVAEDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNI 328

  Fly   231 VHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARL 295
            ..|||:..|||:.|::.||:....|.||.:|..||.:.|.|||:||||:.:      :.|:..|.
  Fly   329 AAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSM------SASSSQRA 387

  Fly   296 ARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLL---QNEHLGLTQLGGFKLVV------ 351
            ||.........|...:.:.|.|.|:|..:||.|....:.   |..::||.    |..||
  Fly   388 ARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLP----FVPVVEGYWNQ 448

  Fly   352 --------GDPLGFLPSHPA----SLATNSSLALPMIIGATKDASAFI---------VSRIYDQL 395
                    .:|  ||..||:    |...||.:|. |....|.:|..||         :|.|.:..
  Fly   449 DSQEEQFYEEP--FLTQHPSDMYHSQNFNSDVAY-MTGYNTHEAMLFIRRLRKNPQLLSIIENDF 510

  Fly   396 ARL--QSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILY 458
            .||  |..||::..|.|.|.              :|..:  :..:...:::|...:..|::.:.
  Fly   511 GRLVPQDLNVTESHDRVTRE--------------IRSFY--LGSKHVGIESVDEMIALLTDLMF- 558

  Fly   459 RAPVINSISQSYR------SVPAYLYTFDYRGE---HHRFGHLSNPLPFGVDASLSDDSVYLFPY 514
                :..|.::.|      :.|.|:|.|.:.|.   :.|.  |..|.| ||  ...|:..|||.:
  Fly   559 ----LQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRM--LGIPRP-GV--CHGDELGYLFKF 614

  Fly   515 PPEASRLNP--LDRSLSRALVTMWVNFATTGVPNPSSGVWPQATSEYGP 561
            ......|:|  ::..:...:|.||.|||..|.|.|.|.. |..|:::.|
  Fly   615 GFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSED-PMLTTKWAP 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	161/563 (29%)
		Aes	<146..345	CDD:223730	77/212 (36%)
		RILP-like	<677..>717	CDD:304877
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	160/554 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910