DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Nlg3

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster

Alignment Length:	1132	Identity:	242/1132 - (21%)
Similarity:	368/1132 - (32%)	Gaps:	369/1132 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NDYSDEDTRRDWLPEPLKPVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIR 91
            |..|:.....|.||.       |..:|....:...:.    |.|:.:.|...   .||.|:.||.
  Fly   137 NSNSNYSPNHDQLPA-------QLSSRIINTRNGAIS----GVIVQLDGRHL---DPVEAYRGIP 187

  Fly    92 YGTVGGGLARFQAAQPIG---YQGRVNATVQSPNCAQ-FPE-------LDRL---------RLSE 136
            |.:...|..||.  .|:.   :.|...|...||.|.| .|:       |:|:         ||..
  Fly   188 YASPPVGNLRFM--PPVSAAMWSGVKKADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLP 250

  Fly   137 SRGENVDDCLTLDIYAP--------EGAN-----------------------------------Q 158
            ......:|||.|:||.|        .|::                                   :
  Fly   251 YLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAK 315

  Fly   159 LPVLVFVHGEMLFDGGSEEAQPDYVLEK--DVLLVSINYRLAPFGFLSALTD---ELPGNVALSD 218
            .|||||||||. ::..|.......||..  .:|:|:|||||...|||:|.||   :||.|..|.|
  Fly   316 YPVLVFVHGES-YEWNSGNPYDGSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMD 379

  Fly   219 LQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHAL--SLSGRAGNLFQQLILQSGTALNPYLI 281
            :..||.||:.|:..|||:...:||.|...||...|.|  |::...|.||.:.||.||:.|.|:.:
  Fly   380 IIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSL 444

  Fly   282 DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLT---Q 343
            .:.|....:..|....|  .|..|.|..:|    ||......||::    :.::....|..   .
  Fly   445 VSNPAKYAAIVAHHVNC--ASDLPHAHLMK----CLREKTLDQLLS----VPIRPPEFGFAFGPS 499

  Fly   344 LGGFKLVVGDPLGFLPSHPAS----------------------------------------LATN 368
            :.|..:..||.:...|..||:                                        .|.|
  Fly   500 IDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAIN 564

  Fly   369 SSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFT 433
            ......::.|.|: |.||......|....:::...|..:...:|:|         ..:.|.|||.
  Fly   565 KLSRYDLMAGVTR-AEAFFSFNSGDVQYGIEADRRSRILKAYVRNT---------YTFHLNEIFA 619

  Fly   434 -----------PIQ----------EQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYL 477
                       |:|          |..:..|.|||.           |..::..|..:|:  :||
  Fly   620 TIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPA-----------AQTVDLHSADHRN--SYL 671

  Fly   478 YTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDR-------SLSRALVTM 535
            |.|||:   .|||    ..|........:|..|:|. .|.....|...|       |||..::..
  Fly   672 YVFDYQ---TRFG----DYPQRQGCIHGEDLPYIFG-APLVGGFNHFTRNYTKTEISLSEVVMFY 728

  Fly   536 WVNFATTGVPNPSSGVWPQATSEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRVIYKPTTNFSP 600
            |.||..||.||      .|..:|:|.  |...::...:|...          |..::|...||.
  Fly   729 WSNFVRTGNPN------EQMETEHGS--RQERSRYKTIEWTA----------YESVHKKYLNFD- 774

  Fly   601 PITTTTTTTTTTTTTSRPYAYNPY-----ANW------------QNRPSQQH------------- 635
                           ::|...|.|     :.|            .|.|:..|
  Fly   775 ---------------TKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIP 824

  Fly   636 --PNWHPADPEYV-RAQEA---------RQQEFIREREQRRREQQLRDQQRYPQQE--PREQQD- 685
              .:..|.:|.|: ||..|         ..|.|.............|:..||...:  |.:..|
  Fly   825 SDASVKPLNPPYISRAANAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKIYPDDMMDG 889

  Fly   686 -----------------------------------------ERIRQQREQEERLRQQREQEERLR 709
                                                     ..:..||: :.||.:.|.|.:..|
  Fly   890 DHAGGAASASQDSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRD-KTRLSEPRPQTKLKR 953

  Fly   710 QQR-ELEERIRQQQEREQYEREQQEREQREREELERQQREREQQQPEQQPEYN--PEPVNPWGYP 771
            |:. ::...|....|......:..     ....|......:..|.|  .||:.  |....|   |
  Fly   954 QENGQMPNNICGDLETLTIHAKSD-----PATILSHHHAMQHHQLP--PPEFADIPHRAPP---P 1008

  Fly   772 VQEPQPDDNPEDG-------------RLPYPSYEQYGPEGNENLPETDANRNFSEEDREQQQQEQ 823
            .:..:...:|..|             ::|.|...|.  .||:  ..|...::..::.:.|.||..
  Fly  1009 PKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPHALQV--MGNQ--CGTLTKKSCMKQTQAQAQQHS 1069

  Fly   824 LRREQQEQQEREYQLQLEREQ--QEREQQER--------GQQEPGPEEYPSYEEYSRALQEKNAE 878
            ..::||:||:::.|..:..:|  |....|..        |...|.|...|       .:.....:
  Fly  1070 PAQQQQQQQQQQQQHVVTHQQHLQNHHNQSMTTVLTTAGGLVVPTPPTVP-------VIVASTTQ 1127

  Fly   879 RDRIYAEEQERERQQQETLLQENQQHP 905
            ..:...:.|:::.|||:.  |:.||||
  Fly  1128 HQQHQQQHQQQQHQQQQQ--QQQQQHP 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	161/664 (24%)
		Aes	<146..345	CDD:223730	73/251 (29%)
		RILP-like	<677..>717	CDD:304877	10/84 (12%)
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	170/731 (23%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	41/97 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930