DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and alpha-Est4

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	146/562 - (25%)
Similarity:	224/562 - (39%)	Gaps:	119/562 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPI-GYQGRVNATVQSP 121
            ::|.|.....|::.||. .|::.:....||.||.|.....|..||:....: .:.|..:.:....
  Fly     7 EDAPVVQTTHGKVRGIL-LKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLS 70

  Fly   122 NCAQFPELDRLRLSESRGENVDDCLTLDIYAPE-GANQLPVLVFVHGEMLFDGGSEEAQ---PDY 182
            .|.|...|.:      ..|..:|||.|:|.... ..:.:||:|::||. .|.||....:   |||
  Fly    71 KCLQVSTLTK------EVEGSEDCLYLNISVKTLNGDPMPVMVYIHGG-AFKGGDSSRRAWGPDY 128

  Fly   183 VLEKDVLLVSINYRLAPFGFLSALTD---ELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVG 244
            .::::|:.:||.:||.|.|||| |.|   |:|||..|.|:.|||.|::.|..:|.|:..::|:.|
  Fly   129 FMKENVVYISIGHRLGPLGFLS-LNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFG 192

  Fly   245 QAGGATLAHALSLSGRAGNLFQQLILQSGTALN----PYL--------------IDNQPLDTLST 291
            .:.|:.....|..|.::..||.:.||.:|.::.    |.:              :|:|.|:.|..
  Fly   193 HSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNVDSQVLEFLLK 257

  Fly   292 FARLARCPPPSINPSAQGLKPLYDCLA-RLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPL 355
                   ..|::..||....||..... .:|....:.::                      ..|.
  Fly   258 -------ADPALIVSADFFTPLEKRQGHNMPFKPSIESY----------------------STPN 293

  Fly   356 GFLPSHPASL-ATNSSLALPMIIGATKDASAFIVSRIY---DQLARLQSRNVSDYIDVVLRHTAP 416
            ..|.:.|..| .|..|..:|:|:||.......|.|.:.   ..|...|. |....:...||:...
  Fly   294 AVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQC-NPERVLPWTLRNRCD 357

  Fly   417 PSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQS---YRSVPAYLY 478
            |.:.|...| ||...|........::.. ..||:||..:....|  ::.:.||   |...|.|||
  Fly   358 PGQRRQLGQ-ALIHHFCEAHGHELTVDH-TNGLVELFTHGFVHA--MDRLIQSRLTYGQAPTYLY 418

  Fly   479 TFD--------YR----GEHHR-FGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRS--- 527
            .||        ||    |:..| .||:             |:..|:|..|....    ||:|
  Fly   419 RFDFDSPDFNFYRIRFMGKEQRGVGHV-------------DELGYIFKLPATFK----LDKSRPE 466

  Fly   528 --LSRALVTMWVNFATTGVPNPSSGVWPQATS--EYGPFLRF 565
              ..|.||.|:|.||.|..||.     |...|  ::.|..||
  Fly   467 FTAIRRLVAMFVQFAATSDPNA-----PLTKSLVDWKPVTRF 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	146/562 (26%)
		Aes	<146..345	CDD:223730	60/224 (27%)
		RILP-like	<677..>717	CDD:304877
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	146/562 (26%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	44/116 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950