DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and alpha-Est5

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	151/566 - (26%)
Similarity:	246/566 - (43%)	Gaps:	81/566 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIG-YQGRVNATVQSPNCAQFPELD 130
            ||||.|:. ..::.:.|..:|..|.:.....|..||:|..|.. :.|.::.|    :.|:.|...
  Fly    17 VGQIKGVK-RLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCT----HYAEKPTQR 76

  Fly   131 RLRLSESRGENVDDCLTLDIYAPE--GANQLPVLVFVHGEMLFDGGS--EEAQPDYVLEKDVLLV 191
            .|...|..|.  :|||.|::|:.:  ....|||:|:::|.....|.:  |...|||.:.|||:||
  Fly    77 GLLTREIEGG--EDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLV 139

  Fly   192 SINYRLAPFGFLSALTD---ELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAH 253
            ::|||:...|||| |.|   ::|||..|.|..|||:|:::.:.:|.|:...:|:.|::.|....|
  Fly   140 TLNYRVDCLGFLS-LKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTH 203

  Fly   254 ALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFA-RLARCPP-PSINPSAQGLKPLYDC 316
            .:..:.:...||.:.|..|||..| |..:|...|    || |||:... ...|..|:.|    :.
  Fly   204 FMMCTEQTRGLFHKAIPMSGTVHN-YWANNPAED----FAFRLAQQNGFTGENDDAKVL----EY 259

  Fly   317 LARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG---FLPSHPASLATNS-SLALPMII 377
            |..:|...||   ...||..||.....|..|...|...:|   .:|..|..:|.:: |...|:::
  Fly   260 LQGVPARDLV---NHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVML 321

  Fly   378 GATKDASAFIVSRIYDQLARLQ--SRNVSDYIDVVLRHTAPPSEHRLWKQWALREIF--TPIQEQ 438
            |.|.....|:...:...|..|.  |::.:..:.|.:|..:...|:..:.|..::..|  :|...:
  Fly   322 GGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSE 386

  Fly   439 TASLQTVAPGLLELSNYILYRA------PVINSISQSYRSVPAYLYTFDYRGEH---HRFGHLSN 494
            .         ||.:.::..|:.      ...|: ..:|...|.|.|.||:...:   :|.....:
  Fly   387 L---------LLNMLDFYSYKIFWHGFNRTFNA-RLTYAKAPTYYYRFDFDSPNFNFYRAKFCGD 441

  Fly   495 PLPFGVDASLSDDSVYLFPYPP--EASRLNPLDRSLSRALVTMWVNFATTGVPN-PSSG--VWPQ 554
            .:..||  :.:||..|||....  :..:.:...|::.| ::.:|..||.|..|| |..|  .|..
  Fly   442 KIKTGV--AHADDLSYLFRNAGSWKLDKTSAEYRTIER-MIGIWTAFAATSNPNCPEIGHLEWKP 503

  Fly   555 ATSEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRV------IYKP 594
            :|.. .| .|..|.......:|        ||.|..      :|||
  Fly   504 STKN-DP-KRVINISSDVTIID--------LPEYEKLQIWDNLYKP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	145/543 (27%)
		Aes	<146..345	CDD:223730	68/207 (33%)
		RILP-like	<677..>717	CDD:304877
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	142/527 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950