DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and alpha-Est7

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	152/563 - (26%)
Similarity:	237/563 - (42%)	Gaps:	120/563 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 WQSET------RYAQ-PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAA 105
            |:.:|      :|.| ..|.||...|.||:.||. ..::.:.|..:|.||.|.....|..||:|.
  Fly    13 WRLKTIEHKVQQYRQSTNETVVADTEYGQVRGIK-RLSLYDVPYFSFEGIPYAQPPVGELRFKAP 76

  Fly   106 Q-PIGYQGRVNATVQSPNCAQFPELDR---LRLSESRGENVDDCLTLDIYA----PEGANQLPVL 162
            | ||.:: ||.      :|:| |: |:   ::....:.|..:|||.|::|.    |:.|.  ||:
  Fly    77 QRPIPWE-RVR------DCSQ-PK-DKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKAR--PVM 130

  Fly   163 VFVHGE--MLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDEL--PGNVALSDLQLAL 223
            |::||.  ::.:...|...|||.:::||:||:|.|||...||:|..:.||  |||..|.|..|||
  Fly   131 VWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLAL 195

  Fly   224 EWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTAL-----------N 277
            :|::.|...|||:...:|:.|::.|....|.:.|:.:...||.:.|||||:|:           |
  Fly   196 KWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHN 260

  Fly   278 PYLI---------DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLL 333
            ||.|         ||.                          |.:.:.|..:....|:...|.:|
  Fly   261 PYRIAKLVGYKGEDND--------------------------KDVLEFLQNVKAKDLIRVEENVL 299

  Fly   334 LQNEHL---------GLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIGATKDASAFIVS 389
            ...|.:         .|......:.|:..|    |......|.::|  :||.||.|.......|.
  Fly   300 TLEERMNKIMFAFGPSLEPFSTPECVISKP----PKEMMKTAWSNS--IPMFIGNTSYEGLLWVP 358

  Fly   390 RIYDQLARLQSRNV-SDYIDVVLRHTAPPSEHRLWKQWA--LREIFTPIQEQTASLQTVAPGLLE 451
            .:......||..:. :.:|...|..| .||:.:| ..|:  :|::.....|.|..      ..::
  Fly   359 EVKLMPQVLQQLDAGTPFIPKELLAT-EPSKEKL-DSWSAQIRDVHRTGSESTPD------NYMD 415

  Fly   452 LSNYILYRAP---VINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGV-DASLSDDSVYLF 512
            |.:...:..|   |::|........|.|.|.:|:..|...|.:....|..|| ..|.:||..|.|
  Fly   416 LCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQF 480

  Fly   513 P------YPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSS 549
            .      .|.|:.....::|:     |.:|..||.||  ||.|
  Fly   481 SSLLARRLPKESREYRNIERT-----VGIWTQFAATG--NPYS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	149/550 (27%)
		Aes	<146..345	CDD:223730	66/235 (28%)
		RILP-like	<677..>717	CDD:304877
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	146/545 (27%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	40/106 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467432
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950