DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	135/558 - (24%)
Similarity:	220/558 - (39%)	Gaps:	156/558 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SGHKTIANRPVNAFLGIRYGTV-GGGLARFQ----AAQPIGYQGRVNATVQSPNCAQFPELDRLR 133
            |..|.||:.......|:::.:: |.....|:    |..|:| :.|..|.|:..:.:.......:|
  Fly    29 SNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVG-ELRFKAPVEPEHWSDVKRCTHVR 92

  Fly   134 ---------LSESRGENVDDCLTLDIYAPE--GANQLPVLVFVHGEMLFDGGSEEAQ-------P 180
                     |.:.:|.  :|||.|::|..|  ....|||||:::|     ||.:..:       |
  Fly    93 AKPCQVNIVLKQVQGS--EDCLYLNVYTRELHPHRPLPVLVWIYG-----GGFQMGEASRDLYSP 150

  Fly   181 DYVLEKDVLLVSINYRLAPFGFLSALTDEL--PGNVALSDLQLALEWLQRNVVHFGGNAGQVTLV 243
            ||::.:.|:||.|:|||...||||...:||  |||..|.|..:||.|::||...|||:...:|:.
  Fly   151 DYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVF 215

  Fly   244 GQAGGATLAHALSLSGRAGNLFQQLILQSGTALNP-------------------YLIDNQPLDTL 289
            |::.|....|.:.|:.:|..||.:.|:.||:||.|                   |..|....|
  Fly   216 GESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRD-- 278

  Fly   290 STFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVG-- 352
             .||.|.:|.                     .:|.|..|.:.:.::..|..||.. .|...:.
  Fly   279 -IFAHLKKCK---------------------ASSMLKVAEDIITMEERHQRLTMF-SFGPTIEPY 320

  Fly   353 -DPLGFLPSHPASLATNS-SLALPMIIGATKDASAFI---VSRIYDQLARLQSRNVSDYIDVVLR 412
             .|...:|..|..:..:. ..::||:||........:   |::..:.|.:|..          ..
  Fly   321 LTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGD----------CE 375

  Fly   413 HTAPPSEHRLWKQ-----WALREIFTPIQEQTASLQTVAPGLLELSNYILYR------------- 459
            :.||...|...:|     ..:||::  ..::|...:|:    ||.|:...|:
  Fly   376 NLAPQDAHVDEQQRKAFGKKVRELY--FGDRTPGRKTI----LEYSDLFSYKYFWHGIHRTLLSR 434

  Fly   460 ---APVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASL-----------SDDSVY 510
               ||:          .|.:||.||:..:|           |.:...:           :||..|
  Fly   435 AHHAPL----------APTFLYRFDFDSKH-----------FNIMRIITCGRKVRGTCHADDLSY 478

  Fly   511 LFPYPPEASRL--NPLDRSLSRALVTMWVNFATTGVPN 546
            || |...|.:|  ...:....:.||:|.|:||.:|.||
  Fly   479 LF-YNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	135/558 (24%)
		Aes	<146..345	CDD:223730	68/228 (30%)
		RILP-like	<677..>717	CDD:304877
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	135/558 (24%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	41/109 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467427
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940