DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Est-P

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	135/523 - (25%)
Similarity:	210/523 - (40%)	Gaps:	105/523 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GLARFQAAQPIGYQGR--VNATVQSP-NCAQFPELDRLRLSESR---GENVDDCLTLDIYAPEGA 156
            |..||:|.||..:...  .||| ||| .|.|:.:.    ::|:.   |:  :||||:.||.|:..
  Fly    56 GALRFEAPQPYSHHWTDVFNAT-QSPVECMQWNQF----INENNKLMGD--EDCLTVSIYKPKKP 113

  Fly   157 NQ--LPVLVFVH-GEMLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSD 218
            |:  .||:|.:| |..:|..||.......:.|..:|:|.|::.|.|.||.|.....||||..|.|
  Fly   114 NRSSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKD 178

  Fly   219 LQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDN 283
            .:|||:|:::|:.||||....:.|:|.:.|...||...|.....:|.:..|..||.||:|::|..
  Fly   179 QRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQ 243

  Fly   284 QPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFK 348
            ..........|:..|  ...|.||:    |.|||...|.|.:|:|....|:    ........|.
  Fly   244 GGRRRAFELGRIVGC--GHTNVSAE----LKDCLKSKPASDIVSAVRSFLV----FSYVPFSAFG 298

  Fly   349 LVV---GDPLGFLPSHPASLATNSSLA-LPMIIGATKDASAFIVSRIYDQLARLQSRNV---SDY 406
            .||   ..|..||...|.::..:...| :|..:..|.:...:       ..|:|..||.   ..:
  Fly   299 PVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGY-------NAAQLLERNKLTGESW 356

  Fly   407 IDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTAS----------LQTVAPGLLELSNY------ 455
            ||::         :..|..||...:|....::|..          .|.:|.....:.:|
  Fly   357 IDLL---------NDRWFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRM 412

  Fly   456 ---ILYRAPVINSIS--QSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLS---------- 505
               :|::..|.::|.  :.|...|.|.:.:|            ||...||...||
  Fly   413 FTDVLFKNSVPSAIDLHRKYGKSPVYSFVYD------------NPTDSGVGQLLSNRTDVHFGTV 465

  Fly   506 --DDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGVWPQATSEYGPFLRFTNN 568
              ||...:|......:.:.|.:..:|:..:.|..:||..          .:.|..:|. ..|.||
  Fly   466 HGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALN----------DKGTLTFGE-CNFQNN 519

  Fly   569 QQS 571
            ..|
  Fly   520 VNS 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	135/523 (26%)
		Aes	<146..345	CDD:223730	66/201 (33%)
		RILP-like	<677..>717	CDD:304877
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	135/523 (26%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	49/132 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930