DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces5a

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	168/606 - (27%)
Similarity:	253/606 - (41%)	Gaps:	126/606 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AVVQAPEVGQILG-ISGHK-TIANR--PVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQ 119
            :|.:.|.....|| :.|.: |:..|  |||.||||.:.....|..||...| ||.:.....||..
  Rat    26 SVTEEPHRYTRLGWVQGKQATVLGRLEPVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTY 90

  Fly   120 SPNCAQ---------------FPELDRLRLSESRGENVDDCLTLDIYAPEGAN---QLPVLVFVH 166
            ...|.|               :|   :|.:||       |||.|:||||..||   :|||::::.
  Rat    91 PNVCFQNLEWLFIYQNLLKVHYP---KLGVSE-------DCLYLNIYAPAYANDGSRLPVMMWIP 145

  Fly   167 G-------EMLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALE 224
            |       ..:|||.:..|.      :|||:|:|.|||..|||.:......|||.|..|...||:
  Rat   146 GGGFETGSASIFDGSALAAY------EDVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQ 204

  Fly   225 WLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYL--IDNQPLD 287
            |::.|:.:||||...||:.|.:.||....:|.||..:..||.:.|:|||.|:.|.|  .|::...
  Rat   205 WVRENINYFGGNPDSVTIFGGSAGAISISSLILSPLSAGLFHRAIMQSGVAIIPSLKNFDDELKH 269

  Fly   288 TLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVG 352
            .|...|.:.:|   :::.|    |.|..||....:.:|::           ||.......::|.|
  Rat   270 GLQVVADVCKC---NVSDS----KVLLKCLREKSSLELLS-----------LGQKTKAFTRVVDG 316

  Fly   353 DPLGFLPSHPASLATNSSL-ALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDV--VLRHT 414
               .|.|..|..|.:..:. .:|.|||.......:|:. :.:....|...|.|..:.:  ||.|.
  Rat   317 ---SFFPEEPMELLSQKTFKTVPSIIGVNNQECGYILP-MREAPEILFGSNESTALTLIHVLLHI 377

  Fly   415 APPSEHRLWKQW-----ALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSV- 473
            .|...|.:.|.:     :|.:|...:.:....:..|.|||:...|               :|..
  Rat   378 PPQYMHIVAKDYFHGKHSLTDIRDTLLDLFGDVFFVVPGLVTARN---------------HRDAG 427

  Fly   474 -PAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYP---------PEASRLNPLDRSL 528
             |.|.|.|     .||.....|..|..|.|..:|:..::|..|         .||:....|   |
  Rat   428 GPVYFYEF-----QHRPNCFQNTRPAFVKADHTDEIRFVFGGPFLEGDVVMFEEATEDEKL---L 484

  Fly   529 SRALVTMWVNFATTGVPNPSS-GVWPQATSEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRVIY 592
            ||.:::.|.|||.:|.||... .:||.           .:..:|.|:||.:...|..|.:.||.:
  Rat   485 SRKMMSYWANFARSGDPNGDDLPLWPA-----------YDQNESYLKLDVNISTGWRLKDRRVEF 538

  Fly   593 KPTTNFSPPITTTTTTTTTTT 613
              .|:..|.||:.:....:.|
  Rat   539 --WTDTLPLITSASKALLSPT 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	159/570 (28%)
		Aes	<146..345	CDD:223730	69/210 (33%)
		RILP-like	<677..>717	CDD:304877
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	155/560 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840