DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces4a

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	152/558 - (27%)
Similarity:	227/558 - (40%)	Gaps:	110/558 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNCAQFPELDR 131
            |.:.|...|  :.:.|:..|||:.:.....|..||...: |:.:.|..:||...|:|
  Rat    41 GILQGKQVH--VGDTPIRVFLGVPFSQPPVGTRRFAPPEPPLPWNGIRDATTYPPSC-------- 95

  Fly   132 LRLSESRGENV----------------DDCLTLDIYAP---EGANQLPVLV-FVHGEMLFDGGSE 176
              |.||.|:..                :|||.|::|||   .|...|||:| |..|..|....|.
  Rat    96 --LQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGDPLLPVMVWFPGGAFLVGSAST 158

  Fly   177 EAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVT 241
            ....:......|:||.:.|||...||.|.......||..|.|...||.|:|.|:..|||:...||
  Rat   159 YEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIAALRWVQENIEAFGGDPDSVT 223

  Fly   242 LVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPS 306
            |.||:.||.....|.:|..|..||.|.|.|||||:....|.:.||.:....|.||.|...|
  Rat   224 LFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDPLKSAKKIAHLAGCDHNS---- 284

  Fly   307 AQGLKPLYDCLARLPTSQLVAAFEQLLL--QNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNS 369
               .|.:..||..||..:::...:::..  .|.|.....:..|...|.|.|.| |..|..|.|..
  Rat   285 ---TKIMVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLSPVVDGLVF-PEDPVVLLTRG 345

  Fly   370 SL-ALPMIIGATKD----ASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALR 429
            .: .:|.::|....    :..|::....:|  |:.::|   ||..:|              |:..
  Rat   346 QVKPVPYLLGVNSAEFEWSLPFLMKLQLNQ--RIMNKN---YITKLL--------------WSCS 391

  Fly   430 EIFTPIQEQTASLQTVAPGLLELS----NYILYRAPVINSISQS---YRSV-----------PAY 476
            .:....:||   :..||...|..:    ::.::|..:|:.:..:   |.::           |.|
  Rat   392 ILLNITEEQ---IPLVAREYLSDAISHHDWKMFRNHLIDLVGDATFVYATLQAARYHRDAGSPVY 453

  Fly   477 LYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLF--PYPPEASRLNPLDRSLSRALVTMWVNF 539
            ||.|    :||..|.:..|...|.|.  .|:..|||  |:...:||..  ::..|..::..|.||
  Rat   454 LYEF----KHHAPGIIVKPRSDGADH--GDELSYLFGSPFSKGSSRGE--EKEFSLQMMKYWANF 510

  Fly   540 ATTGVPNPSS-GVWPQATSEYGPFLRFTNNQQSPLELD 576
            |.||.||... ..||          || :.::..|:||
  Rat   511 AHTGDPNDRELPYWP----------RF-DKEEKYLQLD 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	152/558 (27%)
		Aes	<146..345	CDD:223730	69/204 (34%)
		RILP-like	<677..>717	CDD:304877
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	152/558 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336415
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850