DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2g

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	141/525 - (26%)
Similarity:	226/525 - (43%)	Gaps:	72/525 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVNATV 118
            |:.:.::....||:.|...|.......|:.||||.:.....|..||   :|.:|  :.|..:.|.
  Rat    30 PESSPIRNTHTGQVQGKLTHSKDFKSGVHTFLGIPFAKAPVGPLRFAPPEAPEP--WSGVRDGTS 92

  Fly   119 QSPNCAQ-----FPELDRLRLSESRGENVDDCLTLDIYAPEGANQ---LPVLVFVHGEML----- 170
            ||..|.|     ...|..::|:.......:|||.|:||||..|::   |||:|::||..|
  Rat    93 QSNICPQNVRMNMEGLKEMKLTLPPVSMSEDCLYLNIYAPAHAHEGSHLPVMVWIHGGALTVGMA 157

  Fly   171 --FDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHF 233
              :||....|      .:||::|:|.|||...||.|.......||....|...||.|:|:|:.||
  Rat   158 SMYDGSMLAA------TEDVVVVTIQYRLGVLGFFSTGDHHARGNWGYLDQVAALRWVQQNIAHF 216

  Fly   234 GGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARC 298
            |||...||:.|::.|.....:..:|..:..||.:.|::||.||.|..|.|..........:|:.|
  Rat   217 GGNPDCVTIFGESAGGLSVSSHVVSPMSKGLFHRAIMESGVALMPGTIFNFSEMVYQMVVKLSGC 281

  Fly   299 PPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG-FLPSHP 362
              .:::|.:     |..||......|:....::               |:::.....| |||:||
  Rat   282 --EAMDPES-----LVHCLRGKSEEQITVISKE---------------FQMIPAVVDGEFLPNHP 324

  Fly   363 ASLATNSSL-ALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAP----PSEHRL 422
            ..|..::.. .:|.|||...|...:||.::......::. ...:.:...|:.|||    |.|
  Rat   325 QELLASADFHPVPSIIGFNNDEYGWIVPKVIGSAQTIKG-ITRENLQAFLKDTAPQMMLPPE--- 385

  Fly   423 WKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRS-VPAYLYTFDYRGEH 486
            .....:.|....|::.    ||:.....|:....::..|.: .:::..|| .|.|.|.|     .
  Rat   386 CSDLLMEEYMGDIEDP----QTLQAQFTEMMEDFMFVIPSL-QVARFQRSHAPVYFYEF-----Q 440

  Fly   487 HRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPL--DRSLSRALVTMWVNFATTGVPNPSS 549
            |:...|.:..|..|.|...|:..::|.......:||..  ::.|:|.::..|.|||..|.||.:|
  Rat   441 HQSSFLKDIRPPHVKADHGDEVPFVFGSFFWGMKLNLTEGEKLLNRRMMKYWANFARYGNPNSNS 505

  Fly   550 -GVWP 553
             ..||
  Rat   506 LPYWP 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	141/525 (27%)
		Aes	<146..345	CDD:223730	62/208 (30%)
		RILP-like	<677..>717	CDD:304877
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	140/524 (27%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	41/108 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840