Protein Alignment Glt and CES4A

DIOPT Version :10

• Sequence 1: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 161/606 - (26%)
• Similarity: 235/606 - (38%)
• Gaps: 153/606 - (25%)

  Fly    65 PEV----GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSP--N 122
            |:|    |.:.|...|  :...|:..|||:.:.....|:.||...: |..::|..:||...|  :
Human    50 PQVVTKYGTLQGKQMH--VGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWS 112

  Fly   123 CAQFP---ELDRLRLSESRGENV-----------------------------------------D 143
            .|..|   .:.|.||:.:....|                                         :
Human   113 LALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSE 177

  Fly   144 DCLTLDIYAP---EGANQLPVLV-FVHGEMLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFL- 203
            |||.|::|||   .|..||||:| |..|..:....|.....|....:.|:||.:.:||..||||
Human   178 DCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAASSYEGSDLAAREKVVLVFLQHRLGIFGFLR 242

  Fly   204 -SALTDE--LPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLF 265
             ...||:  ..||..|.|...||.|:|.|:..|||:.|.|||.||:.||.....|.:|..|..||
Human   243 WRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLF 307

  Fly   266 QQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAA-- 328
            .:.|.||||||....|.:.||......|.||.|       :....:.|.:||..|..::::..
Human   308 HRAISQSGTALFRLFITSNPLKVAKKVAHLAGC-------NHNSTQILVNCLRALSGTKVMRVSN 365

  Fly   329 ---FEQLLLQNEH----LGLTQLGGFKLVVGDPL-----GFLPSHPASLATNS---SLALPMIIG 378
               |.||..|.:.    ..::.:....::..|||     |.:.|.|..|..|:   :..||.|:.
Human   366 KMRFLQLNFQRDPEEIIWSMSPVVDGVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMK 430

  Fly   379 ATKDASAF----IVSRIYDQLARLQSRN------VSDYIDVVLRHTAPPSEHRLWKQWALREIFT 433
            ...:..|.    |...::.....|....      |.:|:|.|..|.        ||....| :..
Human   431 FPLNRQAMRKETITKMLWSTRTLLNITKEQVPLVVEEYLDNVNEHD--------WKMLRNR-MMD 486

  Fly   434 PIQEQT---ASLQTVAPGLLELSNYILYRAPVINSISQSYR--SVPAYLYTFDYRGEHHRFGHLS 493
            .:|:.|   |:|||        ::|              :|  .:|.|||.|    |||..|.:.
Human   487 IVQDATFVYATLQT--------AHY--------------HRDAGLPVYLYEF----EHHARGIIV 525

  Fly   494 NPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSG---VWPQA 555
            .|...|.|.  .|:..:||..|.........:::||..::..|.|||.||  ||:.|   .||:
Human   526 KPRTDGADH--GDEMYFLFGGPFATGLSMGKEKALSLQMMKYWANFARTG--NPNDGNLPCWPR- 585

  Fly   556 TSEYGPFLRFTNNQQSPLELD 576
                      .|..:..|:||
Human   586 ----------YNKDEKYLQLD 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_477504.1	COesterase	58..579	CDD:395084	161/606 (27%)
		Casc1_N	681..>717	CDD:464947
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	161/606 (27%)