DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Tg

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	141/582 - (24%)
Similarity:	233/582 - (40%)	Gaps:	105/582 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VQAPEV-----GQILGISGHKTI----ANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRVNAT 117
            :..|.|     ||:.|  |.:.:    |.:.|..|||:.|........||||.:.:.:.|..:||
  Rat  2197 ISTPSVHIDSFGQLQG--GSQVVKVGTAWKQVYQFLGVPYAAPPLAENRFQAPEVLNWTGSWDAT 2259

  Fly   118 VQSPNCAQ-------FPELDRLRLSESRGENVDDCLTLDIYAPEG-ANQLPVLVFVHGEMLFDGG 174
            ....:|.|       .|::.            :|||.|:::.||. .:...||||.|..:..:|.
  Rat  2260 KLRSSCWQPGTRTPTPPQIS------------EDCLYLNVFVPENLVSNASVLVFFHNTVEMEGS 2312

  Fly   175 SEEAQPD---YVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGN 236
            ..:...|   .....::::|:.||||..|||||:.:||:.||..|.|...||.|:|.::..|||:
  Rat  2313 GGQLNIDGSILAAVGNLIVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTWVQTHIGAFGGD 2377

  Fly   237 AGQVTLVGQAGGATLA--HALSLSGRAGNLFQQLILQSGTALNPYLI--DNQPLDTLSTFARLAR 297
            ..:|||....|||.:|  |.|........||::.:|..|:||:|..|  .::.....:..|:...
  Rat  2378 PQRVTLAADRGGADVASIHLLITRPTRLQLFRKALLMGGSALSPAAIISPDRAQQQAAALAKEVG 2442

  Fly   298 CPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGF----KLVVGDPLGFL 358
            ||..|:       :.:..|..:.|.:.|..|..:||..:        |.|    .:|.|..|..|
  Rat  2443 CPNSSV-------QEVVSCFRQKPANILNEAQTKLLAVS--------GPFHYWGPVVDGQYLREL 2492

  Fly   359 PSHPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSR-NVSDYIDVVLRHT--APPSEH 420
            ||.  .|.....:.:.::||.::|......::...|....|.| |........|:::  ...|:.
  Rat  2493 PSR--RLKRPLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAFYQALQNSLGGEDSDA 2555

  Fly   421 R-----LWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTF 480
            |     :|        :..::..|....:.:..|...:.......|::|..|...|.....::.:
  Rat  2556 RILAAAIW--------YYSLEHSTDDYASFSRALENATRDYFIICPIVNMASLWARRTRGNVFMY 2612

  Fly   481 DYRGEH--HRFGHLSNPLPFGVDASLSDDSVYLFP---YPPEASRLNPLDRSLSRALVTMWVNFA 540
                 |  ..:||.|        ..|..|..|.|.   |.......:..::|||..::..:.||.
  Rat  2613 -----HVPESYGHGS--------LELLADVQYAFGLPFYSAYQGYFSMEEQSLSLKVMQYFSNFI 2664

  Fly   541 TTGVPN-PSSGVWPQATSEYG-PFLRFTNNQ--QSPLELDPHFGEGIYLPNYRVIYKPTTNF 598
            .:|.|| |..  :.|..:|:. |:..|....  :|..||...      |||.:.:.|...:|
  Rat  2665 RSGNPNYPHE--FSQKAAEFATPWPDFVPGAGGESYKELSAQ------LPNRQGLKKADCSF 2718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	136/561 (24%)
		Aes	<146..345	CDD:223730	61/206 (30%)
		RILP-like	<677..>717	CDD:304877
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		141/582 (24%)
		COesterase	2198..2719	CDD:278561	141/581 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336484
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930