DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2a

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	145/533 - (27%)
Similarity:	218/533 - (40%)	Gaps:	82/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNAT 117
            :.|...:.::....||:.|...|.......::.||||.:.....|..||...: |..:.|..:||
  Rat    25 HGQDSASPIRNTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDAT 89

  Fly   118 VQSPNCAQ--FPELD---RLRLSESRGENVDDCLTLDIYAP----EGANQLPVLVFVH-GEMLFD 172
            .|...|.|  ...||   .::|:.......:|||.|:||.|    ||:| |||:|::| |.::..
  Rat    90 SQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSN-LPVMVWIHGGGLVLG 153

  Fly   173 GGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNA 237
            ..|..........:::::|||.|||...||.|.......||....|...||.|:|:|:.:||||.
  Rat   154 SASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQVAALRWVQQNIAYFGGNH 218

  Fly   238 GQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPS 302
            |:||:.|.:.|.|...:..:|..:..||...|:|||.||.|.||.::......|.|.|:.|..|.
  Rat   219 GKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDKSEVVYKTVANLSGCEAPD 283

  Fly   303 INPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG-FLPSHPAS-L 365
                   .:.|..|| |..:.|.:.|..|:              ||::.|...| |||.||.. |
  Rat   284 -------SEALIRCL-RAKSKQEILAINQV--------------FKMIPGVVDGKFLPKHPQELL 326

  Fly   366 ATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTA-----PPSEHRLWKQ 425
            |:.....:|.|||...|...:.:. ::..|..:..:...:.:..||:.||     ||
  Rat   327 ASGDFHPVPSIIGINTDECGWGIP-VFLGLDHIIKKITRETLPTVLKSTAAQMMLPP-------- 382

  Fly   426 WALREIFTPIQEQ----TASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEH 486
                |....|.|:    |.:.:|:......:....::..|.:..........|.|.|.|     .
  Rat   383 ----ECIDLIMEEYMGDTENPETLQEQFRHMLGDFMFVIPALQVAHFQRSQAPVYFYEF-----Q 438

  Fly   487 HRFGHLSNPLPFGVDASLSDDSVYLFPYPPEAS-------RLNPLDRSLSRALVTMWVNFATTGV 544
            |....:....|..|.|...||.:::|     .|       .|...:..|.|.::..|.|||.||.
  Rat   439 HLPSFIKQVRPSHVKADHGDDILFVF-----GSYLWGMTFDLTEEEELLKRRVMKYWANFARTGN 498

  Fly   545 PN----PSSGVWP 553
            ||    |.   ||
  Rat   499 PNGEDLPH---WP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	145/532 (27%)
		Aes	<146..345	CDD:223730	66/203 (33%)
		RILP-like	<677..>717	CDD:304877
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	144/528 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840