DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	778	Identity:	185/778 - (23%)
Similarity:	283/778 - (36%)	Gaps:	233/778 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PI 108
            |.| ...|.:.:.:.|.|..|  .:|||          ||:.:||:.|.....|..||...: |.
Mouse    37 PAP-TVNTHFGKLRGARVPLP--SEILG----------PVDQYLGVPYAAPPIGEKRFLPPEPPP 88

  Fly   109 GYQGRVNATVQSPNCAQ-----FPELDRLRLSESRGENVD-----------DCLTLDIYAP---- 153
            .:.|..|||...|.|.|     .||   :.|......|:|           |||.|::|.|
Mouse    89 SWSGIRNATHFPPVCPQNIHTAVPE---VMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDG 150

  Fly   154 EGANQ---------------------LPVLVFVHGEMLFDG------GSEEAQPDYVLEK--DVL 189
            .||.:                     .||:|::||....:|      ||       ||..  :|:
Mouse   151 SGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGS-------VLASYGNVI 208

  Fly   190 LVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHA 254
            ::::|||:...||||.......||..|.|...||.|:..|:..|||:..::|:.|...||:....
Mouse   209 VITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSL 273

  Fly   255 LSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLAR 319
            |:||..:..|||:.|:|||:||:.:.::.||:...|..|....|       :......:.|||.:
Mouse   274 LTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC-------NVLDTVDMVDCLRQ 331

  Fly   320 LPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDP-----LGFLPSHPASLATNSSLALPMIIGA 379
            ....:||.  :.:.....|:....:....::..||     .|...::...|..|....|..:.|.
Mouse   332 KSAKELVE--QDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGV 394

  Fly   380 TKDASAFIVSRIYDQLARLQSRNVSDYIDVV---------LRHTAPPSEHRLWKQWALRE----- 430
            . |....:....:|.       :||:::|.:         ||.|.    ..::..||.|:
Mouse   395 V-DPEDGVSGTDFDY-------SVSNFVDNLYGYPEGKDTLRETI----KFMYTDWADRDNPETR 447

  Fly   431 ------IFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRF 489
                  :||       ..|.|.|.::....:..|.:             |.|.|.|     :|..
Mouse   448 RKTLVALFT-------DHQWVEPSVVTADLHARYGS-------------PTYFYAF-----YHHC 487

  Fly   490 GHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDR----------SLSRALVTMWVNFATTGV 544
            ..|..|.  ..||:..|:..|:|..|    .:.|.|.          .||..::|.|.|||.||.
Mouse   488 QSLMKPA--WSDAAHGDEVPYVFGVP----MVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGD 546

  Fly   545 PNPSSGVWPQAT---------------SEYGP----FL------RFTNNQQSP-----LELDPHF 579
            ||...   ||.|               |:|.|    :|      |..::.::.     ..|.||
Mouse   547 PNKPV---PQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPH- 607

  Fly   580 GEGIYLPNYRVIYKPTTNFSPPITTTTTTTTT------TTTTSRPYAYNPYANWQNRPSQQHPNW 638
               :|..:....|..||...||..||.::..|      |.:|.||.....|:| :|.|.    :|
Mouse   608 ---LYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSN-ENAPG----SW 664

  Fly   639 H---PADPEYVRAQEARQQEF--------------------IREREQRRREQQLRDQQRYPQQ 678
            :   .|.|..|........|.                    :..|:.:||::.||  |..||:
Mouse   665 NGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLR--QPSPQR 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	151/638 (24%)
		Aes	<146..345	CDD:223730	62/231 (27%)
		RILP-like	<677..>717	CDD:304877	1/2 (50%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	151/639 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668		14/50 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840