DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and Ces1a

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001013786.2	Gene:	Ces1a / 244595	MGIID:	3648919	Length:	563	Species:	Mus musculus

Alignment Length:	547	Identity:	154/547 - (28%)
Similarity:	233/547 - (42%)	Gaps:	94/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQS 120
            |....:|...:|:.:.:.|    :.:||..|||:.:.....|..||...||......| |.|...
Mouse    24 PVVDTLQGKVMGKYISLEG----SAQPVAVFLGVPFAKPPLGPLRFAPPQPAETWSSVKNTTSYP 84

  Fly   121 PNCAQFPELDRLRLSE---SRGENV-----DDCLTLDIYAP---EGANQLPVLVFVHGEMLFDGG 174
            |.|:|...:..: ||:   ::.|||     :|||.|:||:|   ...::|||:|:|||..|..||
Mouse    85 PMCSQITGVGPV-LSDVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGG 148

  Fly   175 SEEAQP-DYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAG 238
            :..... .....::|::|.|.|||..:||||...:...||....|...||:|:|.|:.:|||:..
Mouse   149 ASTFDGLALSTHENVVIVVIQYRLGIWGFLSTGDEHSRGNWGHLDQVAALQWVQNNIANFGGDPS 213

  Fly   239 QVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSI 303
            .|||.|::.|......|.||....||||:.|.:||.||.|.|............|....|...:
Mouse   214 SVTLFGESAGGESVSVLVLSPLTKNLFQRAISESGVALTPCLFRETTRRAAEQVAIATGCVATT- 277

  Fly   304 NPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGG------FKLVVGDPLGFLPSHP 362
              ||.    :..||......:|:|.    .|:.:...|..||.      |...|.|.: .||..|
Mouse   278 --SAD----IVHCLREKTEEELLAT----TLKMKFFALDLLGDPRESYPFLTTVIDGV-VLPKAP 331

  Fly   363 AS-LATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHR----- 421
            .. ||..|...:|.|:|..|....:                   :|.:::.:  |.||.:
Mouse   332 EEILAEKSFNTVPYIVGINKQEFGW-------------------FIPMMMGY--PLSEGKLDQKS 375

  Fly   422 ----LWKQWALREI---FTPIQEQTASLQTVAPG-----LLELSNYILYRAPVINSISQSYR--S 472
                |||.:.|..|   .||:..:.....:..|.     .|::...:|:..|.: .:::.:|  .
Mouse   376 ATSLLWKSYPLTNISKELTPVATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPSV-IVARYHRDAG 439

  Fly   473 VPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDD--SVYLFPYPPEASRLNPLDRSLSRALVTM 535
            .|.|:|.|.|   |..|  :|:..|..|.|...|:  ||:..|:..|.:....:  :||..::..
Mouse   440 APTYMYEFKY---HPSF--VSDMRPKTVIADHGDEVYSVWGTPFLKEGASEEEI--NLSTMMMKF 497

  Fly   536 WVNFATTGVPNPSSGV--WPQATSEYG 560
            |.|||..|.|| ..|:  ||    |||
Mouse   498 WGNFARNGNPN-GEGLPHWP----EYG 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	154/547 (28%)
		Aes	<146..345	CDD:223730	65/202 (32%)
		RILP-like	<677..>717	CDD:304877
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	153/546 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850