DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces1c

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	619	Identity:	161/619 - (26%)
Similarity:	260/619 - (42%)	Gaps:	122/619 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 WLPEPLKPVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF 102
            |......|: |.|....:.|.....:...:|:.:.:.|.    .:||..|||:.:.....|..||
  Rat     8 WASLAACPI-WASGHPSSPPVVDTTKGKVLGKYVSLEGF----TQPVAVFLGVPFAKPPLGSLRF 67

  Fly   103 QAAQPIGYQGRV-NATVQSPNCAQFPELDRL---RLSESRGENV-----DDCLTLDIYAPEGA-- 156
            ...:|......| |.|...|.|:|...:.:|   .||..: ||:     :|||.|:||:|...
  Rat    68 APPEPAEPWSFVKNTTTYPPMCSQDGVVGKLLADMLSTGK-ENIPLEFSEDCLYLNIYSPADLTK 131

  Fly   157 -NQLPVLVFVHGEMLFDGGSEEAQPDYVL----EKDVLLVSINYRLAPFGFLSALTDELPGNVAL 216
             ::|||:|::||..|..||   |.|...|    .::|::|:|.|||..:|..|...:...||.|.
  Rat   132 NSRLPVMVWIHGGGLIIGG---ASPYSGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSRGNWAH 193

  Fly   217 SDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI 281
            .|...||.|:|.|:.:||||...||:.|::.|......|.||..|.|||.:.|.:||..|...|.
  Rat   194 LDQLAALRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLD 258

  Fly   282 DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGL-TQLG 345
            ...........|.|:.|.    |.|:..   :..||.:...::|:    :|.::.::..: |.:.
  Rat   259 KKNTQAVAQMIATLSGCN----NTSSAA---MVQCLRQKTEAELL----ELTVKLDNTSMSTVID 312

  Fly   346 GFKLVVGDPLGFLPSHPASLATNSSL-ALPMIIGATKDASAFIV----------SRIYDQLARLQ 399
            |   ||      ||..|..:.|..|. .:|.|:|..|....:|:          .|:.:::|...
  Rat   313 G---VV------LPKTPEEILTEKSFNTVPYIVGFNKQEFGWIIPTMMGNLLSEGRMNEKMASSL 368

  Fly   400 SR------NVSD-----YIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELS 453
            .|      |:|:     .|:..||.|..|::.        :|:                 ||::.
  Rat   369 LRRFSPNLNISESVIPAIIEKYLRGTDDPAKK--------KEL-----------------LLDMF 408

  Fly   454 NYILYRAPVINSISQSYR--SVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDD--SVYLFPY 514
            :.:.:..|.: .:|:|.|  ..|.|:|.|.||.     ..:|:..|..|.....|:  ||:..|:
  Rat   409 SDVFFGIPAV-LMSRSLRDAGAPTYMYEFQYRP-----SFVSDQRPQTVQGDHGDEIFSVFGTPF 467

  Fly   515 PPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGV--WPQATSEYGPFLRF--TNNQQSPLEL 575
            ..|.:  :..:.:||:.::..|.|||..|.|| ..|:  ||:...:.| :|:.  |..|...|:
  Rat   468 LKEGA--SEEETNLSKLVMKFWANFARNGNPN-GEGLPHWPEYDQKEG-YLQIGATTQQAQKLK- 527

  Fly   576 DPHFGEGIYLPNYRVIYKPTTNFSPPITTTTTTT 609
                ||.:      ..:......:||.|..|..|
  Rat   528 ----GEEV------AFWTELLAKNPPQTEHTEHT 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	150/570 (26%)
		Aes	<146..345	CDD:223730	64/206 (31%)
		RILP-like	<677..>717	CDD:304877
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	152/583 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920