Protein Alignment Glt and CES3

DIOPT Version :9

• Sequence 1: NP_001245946.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 149/564 - (26%)
• Similarity: 228/564 - (40%)
• Gaps: 105/564 - (18%)

  Fly    55 AQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQA---AQPIGYQGRVNA 116
            |||:.........|:.:|:.|    .:|.||.||||.:.....|..||.|   |||  ::|..:|
Human    32 AQPEVDTTLGRVRGRQVGVKG----TDRLVNVFLGIPFAQPPLGPDRFSAPHPAQP--WEGVRDA 90

  Fly   117 TVQSPNCAQFPELDRLRLSESR----GEN-----VDDCLTLDIYA----PEGANQLPVLVFVHGE 168
            :...|.|.|    |...::.||    |:.     .:|||.|::|:    |.|:.: ||:|:|||.
Human    91 STAPPMCLQ----DVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGR-PVMVWVHGG 150

  Fly   169 ML-------FDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWL 226
            .|       :||.:..|.      .||::|::.|||...||.|...:..|||....|:..||.|:
Human   151 ALITGAATSYDGSALAAY------GDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWV 209

  Fly   227 QRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLST 291
            |.|:..|||:...||:.|.:.|.::...|.||..|..||.:.|.|||....|.:||:.|......
Human   210 QENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQK 274

  Fly   292 FARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG 356
            .|....|       |:.....:..||.:....:||.:.:   |:|....||..|          .
Human   275 IANTLAC-------SSSSPAEMVQCLQQKEGEELVLSKK---LKNTIYPLTVDG----------T 319

  Fly   357 FLPSHPASLATNSSL-ALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDV---VLRHTAPP 417
            ..|..|..|...... ::|.::|......::::.|.:..|..::..:..|.:.:   ||.....|
Human   320 VFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVP 384

  Fly   418 SEHRLWKQWALREIFTPIQEQTAS---LQTVAPGLLELSNYILYRAPVINSISQSYR--SVPAYL 477
            .|          .:.|.|.|...|   .|.......|....:....|.: |.|:..|  ..|.:.
Human   385 PE----------MMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTV-SFSRYLRDSGSPVFF 438

  Fly   478 YTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYP---PEASRL-----NPLDRSLSRALVT 534
            |.|     .||....:...|..|.|....:..::|..|   .|:|||     ...::.||..::.
Human   439 YEF-----QHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMA 498

  Fly   535 MWVNFATTGVPNPSS-GVWPQATSEYGPFLRFTNNQQSPLELDP 577
            .|.:||.||.||..: ..|||           .|..:..||::|
Human   499 QWTHFARTGDPNSKALPPWPQ-----------FNQAEQYLEINP 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	149/564 (26%)
		Aes	<146..345	CDD:223730	65/209 (31%)
		RILP-like	<677..>717	CDD:304877
CES3	NP_079198.2	COesterase	32..547	CDD:278561	149/564 (26%)
		Aes	<129..>247	CDD:223730	42/124 (34%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840