DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2e

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001157228.1	Gene:	Ces2e / 234673	MGIID:	2443170	Length:	559	Species:	Mus musculus

Alignment Length:	575	Identity:	155/575 - (26%)
Similarity:	237/575 - (41%)	Gaps:	112/575 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YAQPQEAV--VQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF---QAAQPIGYQG- 112
            :.|.|::.  ::....||:.|...|....:..|:.||||.:.....|..||   :|.:|  :.|
Mouse    23 HVQGQDSASPIRNTHTGQVRGSLVHVKDTDIAVHTFLGIPFAKPPVGPLRFAPPEAPEP--WSGV 85

  Fly   113 -----RVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAP----EGANQLPVLVFVHGE 168
                 ..|..:|:.|.....:|..:.|........:|||.|:||.|    ||:| |||:|::||.
Mouse    86 RDGTSHPNMCLQNDNLMGSEDLKMMNLILPPISMSEDCLYLNIYVPAHAHEGSN-LPVMVWIHGG 149

  Fly   169 ML-------FDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWL 226
            .|       :||....|      .:||::|:|.|||...||.|.......||....|...||.|:
Mouse   150 ALTVGMASMYDGSMLAA------TEDVVVVAIQYRLGVLGFFSTGDQHAKGNWGYLDQVAALRWV 208

  Fly   227 QRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLST 291
            |:|:||||||..:||:.|::.|.|...:..:|..:..||...|::||.|:.|.||.:........
Mouse   209 QQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSEMVHRI 273

  Fly   292 FARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG 356
            .|.|:.|       :|...:.|..||.....::::|..:.               ||::.|...|
Mouse   274 VANLSGC-------AAVNSETLMCCLRGKNEAEMLAINKV---------------FKIIPGVVDG 316

  Fly   357 -FLPSHPASL-ATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSE 419
             |||.||..| |:.....:|.|||...|...:|:..|.|...:         |:.:.|.|.|
Mouse   317 EFLPKHPQELMASKDFHPVPSIIGINNDEYGWILPTIMDPAQK---------IEEITRKTLP--- 369

  Fly   420 HRLWKQWALREIFTP-----IQEQ----TASLQTVAPGLLELSNYILYRAPVINSISQSYRS-VP 474
             .:.|..||:.:..|     :.|:    |...:|:.....|:....::..|.: .::...|| .|
Mouse   370 -AVLKSTALKMMLPPECGDLLMEEYMGDTEDPETLQAQFREMKGDFMFVIPAL-QVAHFQRSHAP 432

  Fly   475 AYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLF---------PYPPEASRLNPLDRSLSR 530
            .|.|.|     .||.....:..|..|.|...|:...:|         ||..|       :..|||
Mouse   433 VYFYEF-----QHRPSFFKDFRPPYVKADHGDEIFLVFGYQFGNIKLPYTEE-------EEQLSR 485

  Fly   531 ALVTMWVNFATTGVPNPSSGV--WPQATSEYGPFLRFTNNQQSPLELDPHFGEGI 583
            .::..|.|||..|.|| |.|:  ||....:         .|...|::.|..|..:
Mouse   486 RIMKYWANFARHGNPN-SEGLPYWPVMDHD---------EQYLQLDIQPSVGRAL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	154/568 (27%)
		Aes	<146..345	CDD:223730	65/209 (31%)
		RILP-like	<677..>717	CDD:304877
Ces2e	NP_001157228.1	COesterase	30..538	CDD:278561	153/568 (27%)
Ces2e	NP_001157228.1	Aes	<128..>231	CDD:223730	43/109 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840