DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2c

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	574	Identity:	149/574 - (25%)
Similarity:	229/574 - (39%)	Gaps:	118/574 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVNATV 118
            |:...::....|||.|...|.......|:.||||.:.....|..||   :|.:|  :.|..:.|.
Mouse    30 PEANPIRNTHTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEP--WSGVRDGTA 92

  Fly   119 QSPNCAQFPELDRL--------RLSESRGENVDDCLTLDIYAP----EGANQLPVLVFVHGEML- 170
            ....|.|  .||.|        ::..|.....:|||.|:||.|    ||:| |||:|::||..|
Mouse    93 HPAMCLQ--NLDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSN-LPVMVWIHGGALV 154

  Fly   171 ------FDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRN 229
                  |||..      ..:.:|:::|:|.|||...||.|.......||....|...||.|:|:|
Mouse   155 IGMASMFDGSL------LTVNEDLVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQAAALRWVQQN 213

  Fly   230 VVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFAR 294
            :.|||||..:||:.|::.|.|...:..:|..:..||...|::||.||.|.||........:|.|:
Mouse   214 IAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSEMVSTTVAK 278

  Fly   295 LARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG-FL 358
            |:.|       .|...:.|..||.....::::|..:.               ||::.....| |.
Mouse   279 LSGC-------EAMDSQALVRCLRGKSEAEILAINKV---------------FKMIPAVVDGEFF 321

  Fly   359 PSHPAS-LATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTA-----PP 417
            |.||.. ||:.....:|.|||...|...:.:..:... |::......:.:..||:.||     ||
Mouse   322 PRHPKELLASEDFHPVPSIIGVNNDEFGWSIPVVMGS-AQMIKGITRENLQAVLKDTAVQMMLPP 385

  Fly   418 SEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRS-VPAYLYTF- 480
            ....|        :.......|...||:.....|:....::..|.: .::...|| .|.|.|.|
Mouse   386 ECSDL--------LMEEYMGDTEDAQTLQIQFTEMMGDFMFVIPAL-QVAHFQRSHAPVYFYEFQ 441

  Fly   481 -------DYRGEHHRFGHLSNPLPF-------GVDASLSDDSVYLFPYPPEASRLNPLDRSLSRA 531
                   |.|..|.:..| ::.:||       |:....:::                 :..|||.
Mouse   442 HPPSYFKDVRPPHVKADH-ADEIPFVFASFFWGMKLDFTEE-----------------EELLSRR 488

  Fly   532 LVTMWVNFATTGVPNPSSGV--WPQATSEYGPFLRFTNNQQSPLELDPHFGEGI 583
            ::..|.|||..|.|| |.|:  ||....:         .|...|::.|..|..:
Mouse   489 MMKYWANFARHGNPN-SEGLPYWPVMDHD---------EQYLQLDIQPAVGRAL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	148/568 (26%)
		Aes	<146..345	CDD:223730	65/209 (31%)
		RILP-like	<677..>717	CDD:304877
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	148/573 (26%)
		Aes	<130..>233	CDD:223730	41/109 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840