DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2b

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	566	Identity:	149/566 - (26%)
Similarity:	234/566 - (41%)	Gaps:	95/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVNATV 118
            |:.:.::....||:.|...|.......|:.||||.:.....|..||   :|.:|  :.|..:.|.
Mouse    30 PEASPIRNTHTGQVRGSLVHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEP--WSGVRDGTA 92

  Fly   119 QSPNCAQ-FPELDRLRLSESRGENVDDCLTLDIYAP----EGANQLPVLVFVHG-------EMLF 171
            ....|.| ...:..::|........:|||.|:||.|    ||:| |||:|::||       ..::
Mouse    93 HPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSN-LPVMVWIHGGGLVAGMASMY 156

  Fly   172 DGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGN 236
            ||....|      .:|:::|:|.|||...||.|.......||....|...||.|:|:|:.||||.
Mouse   157 DGSLLAA------IEDLVVVTIQYRLGVLGFFSTGDQHARGNWGFLDQVAALRWIQQNIAHFGGK 215

  Fly   237 AGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPP 301
            ..:||:.|::.|.|...:..:|..:..||...|::||.||.||||.:......:|.|:|:.|
Mouse   216 PDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLITDTSEMVSTTVAKLSGC--- 277

  Fly   302 SINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVV-GDPLGFLPSHPAS- 364
                .|...:.|..||.....::::|..:          |.|:  ...|| |:   |.|.||..
Mouse   278 ----EAMDSEALVRCLRGKSEAEILAINK----------LVQM--IPAVVDGE---FFPRHPKEL 323

  Fly   365 LATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTA-----PPSEHRLWK 424
            ||:.....:|.|||...|...:.:..:... |:.......:.:..||::|.     ||....|
Mouse   324 LASEDFHPVPSIIGVNNDEFGWTIPVVMGS-AQTIKEITRENLQAVLKNTTAQLMLPPECSDL-- 385

  Fly   425 QWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVIN--SISQSYRSVPAYLYTFDYRGEHH 487
                  :.......|...||:.....|:....::..|.:.  ...:|:.||  |.|.|     .|
Mouse   386 ------LMEEYMGDTEDAQTLQIQFTEMMEDFMFVIPALQVAYFQRSHASV--YFYEF-----QH 437

  Fly   488 RFGHLSNPLPFGVDASLSDDSVYLFPY--------PPEASRLNPLDRSLSRALVTMWVNFATTGV 544
            :...|.:..|..|.|..:|:..::|.|        ..|..:|      |||.::..|.|||..|.
Mouse   438 QIASLKDVRPTHVKADHADEIPFVFGYFFWDMKLDFTEGEKL------LSRRMMKYWANFARHGN 496

  Fly   545 PNPSSGVWPQATSEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRV 590
            ||          ||..|:....::.:..|:||.....|..|.:.|:
Mouse   497 PN----------SEGLPYWPVMDHDEQYLQLDTQPAVGRALKSRRL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	146/553 (26%)
		Aes	<146..345	CDD:223730	66/209 (32%)
		RILP-like	<677..>717	CDD:304877
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	148/562 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840