DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and Ces1f

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	548	Identity:	143/548 - (26%)
Similarity:	226/548 - (41%)	Gaps:	110/548 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQSPNCAQFPELDR 131
            |::||...:....::||..||||.:.....|..||...||......| |||...|.|:|    |.
Mouse    31 GKVLGKHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQ----DA 91

  Fly   132 LR------LSESRGENV-----DDCLTLDIYAP---EGANQLPVLVFVHGEML-------FDGGS 175
            .|      |..:|.|.:     :|||.|:||.|   ...::|||:|::||..|       |||.:
Mouse    92 ARGQAVNDLITNRKEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGASSFDGRA 156

  Fly   176 EEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQV 240
            ..|.      ::|::|:|.|||:.:||.|...:...||....|...||.|:|.|:.:|||:.|.|
Mouse   157 LSAY------ENVVVVAIQYRLSIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSV 215

  Fly   241 TLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINP 305
            |:.|::.|......|.||..:.|||.:.|.:||.|..|.:............|..|.|   ....
Mouse   216 TIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQIAVTAGC---KTTT 277

  Fly   306 SAQGLKPLYDCLARLPTSQLVAAFE-----QLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPAS- 364
            ||    .:..|:.:....:|:....     :|.||.:.....|   |...|.|.: .||..|..
Mouse   278 SA----VIVHCMRQKTEEELLEIMHKLNLYKLSLQGDTKNSDQ---FVTSVLDGV-VLPKDPKEI 334

  Fly   365 LATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALR 429
            ||..:...:|.|:|..|....:::..:...|                     |::.:|.|:.|:
Mouse   335 LAEKNFNTVPYIVGINKQECGWLLPTMTGFL---------------------PADVKLDKKKAI- 377

  Fly   430 EIFTPIQEQTASL----QTVAP------------------GLLELSNYILYRAPVINSISQSYR- 471
                .:.||.||:    :.:.|                  |:|:....:.:..|.: .:|:.:|
Mouse   378 ----ALLEQFASMTGIPEDIIPVAVEKYTKGSDDPDQIREGVLDAMGDVAFGVPSV-IVSRGHRD 437

  Fly   472 -SVPAYLYTFDYRGEHHRFGHLSNP-LPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVT 534
             ..|.|:|.:.|      :...|:| .|..|....:||...:|..|......:..:.:||:.::.
Mouse   438 TGAPTYMYEYQY------YPSFSSPQRPKNVVGDHADDVYSVFGAPILREGASEEEINLSKMVMK 496

  Fly   535 MWVNFATTGVPNPSSGV--WPQATSEYG 560
            .|.|||..|.|| ..|:  ||:...:.|
Mouse   497 FWANFARNGNPN-GKGLPHWPKYDQKEG 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	143/548 (26%)
		Aes	<146..345	CDD:223730	63/213 (30%)
		RILP-like	<677..>717	CDD:304877
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	143/548 (26%)
		Aes	<121..>225	CDD:223730	39/109 (36%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850