DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and NLGN1

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001352852.1	Gene:	NLGN1 / 22871	HGNCID:	14291	Length:	843	Species:	Homo sapiens

Alignment Length:	768	Identity:	194/768 - (25%)
Similarity:	287/768 - (37%)	Gaps:	216/768 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 APEVGQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQSPNCA 124
            |...|:|.||.  |.:.|.   ||..|||:.|.....|..|||..:|......: |||..:|.|.
Human    56 ATNFGKIRGIK--KELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCP 118

  Fly   125 Q------FPE----------LDRLRLSESRGENVDDCLTLDIYAP-----------------EGA 156
            |      .||          ||  .:|....:..:|||.|:||.|                 :||
Human   119 QNIIDGRLPEVMLPVWFTNNLD--VVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGA 181

  Fly   157 NQ---------LPVLVFVHGEM-------LFDGGSEEAQPDYVLEK--DVLLVSINYRLAPFGFL 203
            ..         .||:|::||..       |:||.        ||..  :|:::::||||...|||
Human   182 EDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGS--------VLASYGNVIVITVNYRLGVLGFL 238

  Fly   204 SALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRA-GN---- 263
            |.......||..|.||..||.|...|:..|||:..::|:.|...|.:..:.|:||..: ||
Human   239 STGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSN 303

  Fly   264 ----LFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQ 324
                |||:.|.||||||:.:.:..||       |:.||.....:..:......|.:||.:.|..:
Human   304 STKGLFQRAIAQSGTALSSWAVSFQP-------AKYARMLATKVGCNVSDTVELVECLQKKPYKE 361

  Fly   325 LVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSS-LALPMIIGATKDASAFIV 388
            ||.  :.:.....|:...     .::.||   .:|..|..|..... |...:::|..:......|
Human   362 LVD--QDIQPARYHIAFG-----PVIDGD---VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV 416

  Fly   389 SRIYDQLARLQSRN----VSDYID---------VVLRHTAPPSEHRLWKQWALREIFTPIQEQTA 440
            ..|.|....:.:.:    ||:::|         .|||.|.    ..::..||.|.
Human   417 ENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETI----KFMYTDWADRH---------- 467

  Fly   441 SLQTVAPGLLELSNYILYRAPVINS--ISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDAS 503
            :.:|....||.|.....:.||.:.:  :..::.| |.|.|.|    .||   ..::.:|...||:
Human   468 NPETRRKTLLALFTDHQWVAPAVATADLHSNFGS-PTYFYAF----YHH---CQTDQVPAWADAA 524

  Fly   504 LSDDSVYLFPYP---PEASRLNPL-----DRSLSRALVTMWVNFATTGVPNPSSGVWPQATS--- 557
            ..|:..|:...|   |  :.|.|.     |..||..::|.|.|||.||.||...   ||.|.
Human   525 HGDEVPYVLGIPMIGP--TELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV---PQDTKFIH 584

  Fly   558 ------EYGPFLRFTNNQQSPLE--LDPHFGEGIYLPNYR----------VIYKPTTNFSPPITT 604
                  |...:.|::...|..|.  |.|...|     :||          |.:....|.....|:
Human   585 TKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKE-----HYRANKVNLWLELVPHLHNLNDISQYTS 644

  Fly   605 TTTTTTTTTTTSRPYAYN--------PYANWQNRPSQQHPNWHPADPEYVRAQEARQQEFIRE-- 659
            |||...:|..|.||...|        |.|. |:.|.|| |:....|          |:::..|
Human   645 TTTKVPSTDITFRPTRKNSVPVTSAFPTAK-QDDPKQQ-PSPFSVD----------QRDYSTELS 697

  Fly   660 -----------------------REQRRREQQLR-DQQRYPQQEPREQQDERI 688
                                   :::||.:...| ..||....:....|:|.|
Human   698 VTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEI 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	162/613 (26%)
		Aes	<146..345	CDD:223730	68/242 (28%)
		RILP-like	<677..>717	CDD:304877	3/12 (25%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	165/630 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840