Protein Alignment Glt and NLGN4Y

DIOPT Version :9

• Sequence 1: NP_001245946.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 911
• Identity: 209/911 - (22%)
• Similarity: 317/911 - (34%)
• Gaps: 291/911 - (31%)

  Fly    52 TRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVN 115
            |.|.:.|.  ::.|...:|||          ||..:||:.|.:...|..|||..: |..:.|..|
Human    50 TNYGKIQG--LRTPLPSEILG----------PVEQYLGVPYASPPTGERRFQPPESPSSWTGIRN 102

  Fly   116 ATVQSPNCAQF----------------PELDRLRLSESRGENVDDCLTLDIYAP--EGAN----- 157
            ||..|..|.|.                ..||.| ::..:.:| :|||.|:||.|  :|.|
Human   103 ATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTL-MTYVQDQN-EDCLYLNIYVPMEDGTNIKRNA 165

  Fly   158 -------------------QLPVLVFVHGEMLFDGGSEEAQPDYVLE-KDVLLVSINYRLAPFGF 202
                               :.||:|::||....:|.........:.. .:|::::|||||...||
Human   166 DDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGF 230

  Fly   203 LSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQ 267
            ||.......||..|.|...||.|::.||..|||:..:||:.|...||:....|:||..:..|||:
Human   231 LSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQK 295

  Fly   268 LILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLV------ 326
            .|:||||||:.:.::.||       |:..|.....:..:......:.:||......:|:
Human   296 AIIQSGTALSSWAVNYQP-------AKYTRILADKVGCNMLDTTDMVECLKNKNYKELIQQTITP 353

  Fly   327 ----AAF------------EQLLLQNEH-------LGLTQLGGFKLVVGDPLGFLPSHPASLATN 368
                .||            .|:|::...       ||:.|..|.|.|.|            :..|
Human   354 ATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDG------------IVDN 406

  Fly   369 SSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYID--VVLRHTAPPSEHRLWKQWALRE- 430
            ..       |.|.:...|.||...|        |:..|.:  ..||.|.    ..::..||.:|
Human   407 ED-------GVTPNDFDFSVSNFVD--------NLYGYPEGKDTLRETI----KFMYTDWADKEN 452

  Fly   431 ----------IFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGE 485
                      :||       ..|.|||.:.....:..|.:             |.|.|.|    .
Human   453 PETRRKTLVALFT-------DHQWVAPAVATADLHAQYGS-------------PTYFYAF----Y 493

  Fly   486 HHRFGHLSNPLPFGVDASLSDDSVYLFPYP---PE---ASRLNPLDRSLSRALVTMWVNFATTGV 544
            ||....:.   |...|::..|:..|:|..|   |.   :...:..|..||..::|.|.|||.||.
Human   494 HHCQSEMK---PSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGD 555

  Fly   545 PNPSSGVWPQAT---------------SEYGP----FL------RFTNNQQSP-----LELDPHF 579
            ||...   ||.|               |:|.|    :|      |..::.::.     |||.||
Human   556 PNQPV---PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPH- 616

  Fly   580 GEGIYLPNYRVIYK---PTTNFSPPITTTTTTTTTTT------TTSRPYAYNPYANWQNRPSQQH 635
                 |.|...|::   .||...||..|:....|..:      ||.|| |..| ||  |....:.
Human   617 -----LHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRP-AITP-AN--NPKHSKD 672

  Fly   636 PNWHPADPEYVRAQEARQQEFIRE-------------------------REQRRREQQLRDQQRY 675
            |  |...||........::::..|                         :::||.|     ..|:
Human   673 P--HKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHE-----THRH 730

  Fly   676 PQQEPREQQDERIRQQREQEERLRQQREQEERLRQQRELEERIRQQQEREQYEREQQEREQRERE 740
            |.            .||.....:...:.:|....|.::||         ..:|.|..:.....|.
Human   731 PS------------PQRNTTNDITHIQNEEIMSLQMKQLE---------HDHECESLQAHDTLRL 774

  Fly   741 ELERQQREREQQQPEQQPEYNPEPVN--PWGYPVQEPQPDDNPEDGRLPYPSYEQY-GPEGNENL 802
            ..........::.|:..|...|..:.  |            |...|..|..:::.: |.:.:.||
Human   775 TCPPDYTLTLRRSPDDIPFMTPNTITMIP------------NTLMGMQPLHTFKTFSGGQNSTNL 827

  Fly   803 P 803
            |
Human   828 P 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	158/645 (24%)
		Aes	<146..345	CDD:223730	67/254 (26%)
		RILP-like	<677..>717	CDD:304877	6/39 (15%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	156/641 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840