Protein Alignment Glt and CES5A

DIOPT Version :9

• Sequence 1: NP_001245946.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 165/625 - (26%)
• Similarity: 244/625 - (39%)
• Gaps: 144/625 - (23%)

  Fly    22 LRPDYNDYSDED-----------TRRDWLPEPLKPVPWQSETRYAQPQEAVVQAPEVGQILGISG 75
            ||.|..:|:.:|           ||..|:                |.::..|....|
Human    41 LRIDVLNYTSKDEGPSAEGPQRNTRLGWI----------------QGKQVTVLGSPV-------- 81

  Fly    76 HKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRVNATVQSPN-CAQFPE---LDR--LRL 134
                   |||.|||:.:.....|..||...||......:......|| |.|..|   ||:  |::
Human    82 -------PVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKV 139

  Fly   135 SESRGENVDDCLTLDIYAPEGA---NQLPVLVFVHG-------EMLFDGGSEEAQPDYVLEKDVL 189
            ...:....:|||.|:||||..|   ::|||||:..|       ..:|||.:..|.      :|||
Human   140 HYPKFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSASIFDGSALAAY------EDVL 198

  Fly   190 LVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHA 254
            :|.:.|||..|||.:......|||.|..|...||.|:|:|:..|||:...||:.|::.||....:
Human   199 VVVVQYRLGIFGFFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSS 263

  Fly   255 LSLSGRAGNLFQQLILQSGTALNPYL--IDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCL 317
            |.||..|..||.:.|::||.|:.|||  .|.:..:.|...|...       ..:|...:.|..||
Human   264 LILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFC-------GNNASDSEALLRCL 321

  Fly   318 ARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSL-ALPMIIGATK 381
            ...|:.:|      |.|..:....|     ::|.|   .|.|:.|..|.:..:. |:|.|||...
Human   322 RTKPSKEL------LTLSQKTKSFT-----RVVDG---AFFPNEPLDLLSQKAFKAIPSIIGVNN 372

  Fly   382 DASAFIVSRIYDQLARLQSRNVSDYIDVV--LRHTAPPSEHRLWKQWALREIFTPIQEQTASLQT 444
            ....|::. :.:....|...|.|..:.::  :.|..|...|.:     ..|.|    ....||..
Human   373 HECGFLLP-MKEAPEILSGSNKSLALHLIQNILHIPPQYLHLV-----ANEYF----HDKHSLTE 427

  Fly   445 VAPGLLELSNYILYRAPVINSISQSYR---SVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSD 506
            :...||:|...:.:..|.:  |:..|.   ..|.|.|.|     .||.....:..|..|.|..:|
Human   428 IRDSLLDLLGDVFFVVPAL--ITARYHRDAGAPVYFYEF-----RHRPQCFEDTKPAFVKADHAD 485

  Fly   507 D------------SVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSS-GVWP--QAT 556
            :            .:.:|....|..:|      |||.::..|..||.||.||.:. .:||  ..|
Human   486 EVRFVFGGAFLKGDIVMFEGATEEEKL------LSRKMMKYWATFARTGNPNGNDLSLWPAYNLT 544

  Fly   557 SEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRVIYKPTT 596
            .:|             |:||.:...|..|...||.:..:|
Human   545 EQY-------------LQLDLNMSLGQRLKEPRVDFWTST 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	152/562 (27%)
		Aes	<146..345	CDD:223730	70/210 (33%)
		RILP-like	<677..>717	CDD:304877
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	159/605 (26%)
		Aes	<155..>258	CDD:223730	41/108 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840