Protein Alignment Glt and Nlgn2

DIOPT Version :10

• Sequence 1: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 669
• Identity: 178/669 - (26%)
• Similarity: 250/669 - (37%)
• Gaps: 191/669 - (28%)

  Fly    68 GQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNCAQ--- 125
            |::.|:  .:.:.|.   ||..|||:.|.|...|..|||..: |..:.|..|||...|.|.|
Mouse    49 GRVRGV--RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLH 111

  Fly   126 --FPEL-------DRLRLSESRGEN-VDDCLTLDIYAP----------------------EGANQ 158
              .|.:       |.|..:.:..:| .:|||.|::|.|                      ..:.:
Mouse   112 GALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGK 176

  Fly   159 LPVLVFVHGEM-------LFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVAL 216
            .||::|:||..       :|||....|.      .:|::|::||||...||||.......||..|
Mouse   177 KPVMLFLHGGSYMEGTGNMFDGSVLAAY------GNVIVVTLNYRLGVLGFLSTGDQAAKGNYGL 235

  Fly   217 SDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI 281
            .|...||.||..|:.||||:..::|:.|...||:..:.|.||..:..|||:.|.|||||::.:.:
Mouse   236 LDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV 300

  Fly   282 DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLV----------AAF------- 329
            :.|||......|....|       ..:......:||.|..:.:||          .||
Mouse   301 NYQPLKYTRLLAAKVGC-------DREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGD 358

  Fly   330 ------EQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIGATKDASAFIV 388
                  |.|:.|.|.|....|.|..  .|:.|.|:.....|..           |.:..|..|.|
Mouse   359 VVPDDPEILMQQGEFLNYDMLIGVN--QGEGLKFVEDSAESED-----------GVSASAFDFTV 410

  Fly   389 SRIYDQLARLQSRNVSDYID--VVLRHTAPPSEHRLWKQWALRE-----------IFTPIQEQTA 440
            |...|        |:..|.:  .|||.|.    ..::..||.|:           :||
Mouse   411 SNFVD--------NLYGYPEGKDVLRETI----KFMYTDWADRDNGEMRRKTLLALFT------- 456

  Fly   441 SLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLS 505
            ..|.|||.:.....:..|::||             |.|||    .||   ..:...|...||:..
Mouse   457 DHQWVAPAVATAKLHADYQSPV-------------YFYTF----YHH---CQAEGRPEWADAAHG 501

  Fly   506 DDSVYLFPYP-PEASRLNPL-----DRSLSRALVTMWVNFATTGVPNP----------------S 548
            |:..|:|..| ..|:.|.|.     |..||..::|.|.|||.||.||.                .
Mouse   502 DELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE 566

  Fly   549 SGVWPQATSEYGPFL------RFTNNQQSP-----LELDPHFGEGIYLPNYRVIYKPTTNFSPPI 602
            ..||.:..|:...:|      |..:|.::.     |||.||      |.|.......||...||.
Mouse   567 EVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPH------LHNLHTELFTTTTRLPPY 625

  Fly   603 TTTTTTTTT---TTTTSRP 618
            .|.....|.   |:.|.||
Mouse   626 ATRWPPRTPGPGTSGTRRP 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_477504.1	COesterase	58..579	CDD:395084	165/625 (26%)
		Casc1_N	681..>717	CDD:464947
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	161/618 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661		8/22 (36%)
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836