DRSC/TRiP Functional Genomics Resources

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Protein Alignment Glt and Nlgn2

DIOPT Version :9

Sequence 1:NP_001245946.1 Gene:Glt / 34193 FlyBaseID:FBgn0001114 Length:1026 Species:Drosophila melanogaster
Sequence 2:NP_001351066.1 Gene:Nlgn2 / 216856 MGIID:2681835 Length:836 Species:Mus musculus


Alignment Length:669 Identity:178/669 - (26%)
Similarity:250/669 - (37%) Gaps:191/669 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 GQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNCAQ--- 125
            |::.|:  .:.:.|.   ||..|||:.|.|...|..|||..: |..:.|..|||...|.|.|   
Mouse    49 GRVRGV--RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLH 111

  Fly   126 --FPEL-------DRLRLSESRGEN-VDDCLTLDIYAP----------------------EGANQ 158
              .|.:       |.|..:.:..:| .:|||.|::|.|                      ..:.:
Mouse   112 GALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGK 176

  Fly   159 LPVLVFVHGEM-------LFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVAL 216
            .||::|:||..       :|||....|.      .:|::|::||||...||||.......||..|
Mouse   177 KPVMLFLHGGSYMEGTGNMFDGSVLAAY------GNVIVVTLNYRLGVLGFLSTGDQAAKGNYGL 235

  Fly   217 SDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI 281
            .|...||.||..|:.||||:..::|:.|...||:..:.|.||..:..|||:.|.|||||::.:.:
Mouse   236 LDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV 300

  Fly   282 DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLV----------AAF------- 329
            :.|||......|....|       ..:......:||.|..:.:||          .||       
Mouse   301 NYQPLKYTRLLAAKVGC-------DREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGD 358

  Fly   330 ------EQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIGATKDASAFIV 388
                  |.|:.|.|.|....|.|..  .|:.|.|:.....|..           |.:..|..|.|
Mouse   359 VVPDDPEILMQQGEFLNYDMLIGVN--QGEGLKFVEDSAESED-----------GVSASAFDFTV 410

  Fly   389 SRIYDQLARLQSRNVSDYID--VVLRHTAPPSEHRLWKQWALRE-----------IFTPIQEQTA 440
            |...|        |:..|.:  .|||.|.    ..::..||.|:           :||       
Mouse   411 SNFVD--------NLYGYPEGKDVLRETI----KFMYTDWADRDNGEMRRKTLLALFT------- 456

  Fly   441 SLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLS 505
            ..|.|||.:.....:..|::||             |.|||    .||   ..:...|...||:..
Mouse   457 DHQWVAPAVATAKLHADYQSPV-------------YFYTF----YHH---CQAEGRPEWADAAHG 501

  Fly   506 DDSVYLFPYP-PEASRLNPL-----DRSLSRALVTMWVNFATTGVPNP----------------S 548
            |:..|:|..| ..|:.|.|.     |..||..::|.|.|||.||.||.                .
Mouse   502 DELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE 566

  Fly   549 SGVWPQATSEYGPFL------RFTNNQQSP-----LELDPHFGEGIYLPNYRVIYKPTTNFSPPI 602
            ..||.:..|:...:|      |..:|.::.     |||.||      |.|.......||...||.
Mouse   567 EVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPH------LHNLHTELFTTTTRLPPY 625

  Fly   603 TTTTTTTTT---TTTTSRP 618
            .|.....|.   |:.|.||
Mouse   626 ATRWPPRTPGPGTSGTRRP 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GltNP_001245946.1 COesterase 55..579 CDD:278561 165/625 (26%)
Aes <146..345 CDD:223730 69/250 (28%)
RILP-like <677..>717 CDD:304877
Nlgn2NP_001351066.1 COesterase 42..601 CDD:306613 161/618 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661 8/22 (36%)
Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832884
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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