DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2e

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	158/586 - (26%)
Similarity:	242/586 - (41%)	Gaps:	104/586 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LPEPLKPVPWQSETRYAQPQ----EAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGL 99
            ||..|..|.|.....:.|.|    .:.::....||:.|...|.......|:.||||.:.....|.
  Rat     6 LPGWLNAVVWGLLLLFCQVQGQDSASPIRNTHTGQVRGSFVHVKDTKSGVHTFLGIPFAKPPIGP 70

  Fly   100 ARFQAAQ-PIGYQGRVNATVQSPNCAQFPELD-------RLRLSESRGENVDDCLTLDIYAPEGA 156
            .||...: |..:.|..:.|.....|.|  .:|       ::::|.|.....:|||.|.||.|...
  Rat    71 LRFAPPEPPEPWSGVRDGTSHPAMCLQ--NIDGLNLENLKIKMSRSPVSMSEDCLYLSIYTPAHT 133

  Fly   157 NQ---LPVLVFVHGEML-------FDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELP 211
            ::   |||:|::||..|       :||....|      .:||::|:|.|||...||.|...:...
  Rat   134 HKDSNLPVMVWIHGGGLCWGMASTYDGSMLAA------IEDVVVVTIQYRLGILGFFSTGDEHAR 192

  Fly   212 GNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTAL 276
            ||....|...||.|:|:|:||||||..:||:.|::.|.....:..:|..:..||...|::||.||
  Rat   193 GNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVAL 257

  Fly   277 NPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGL 341
            .|.||.|......:..|.|:.|.|  ::..|     |..||......:::|.        .::..
  Rat   258 LPNLISNTSEVIYTMVANLSGCEP--VDSEA-----LMSCLREKSEEEMLAI--------NNIVR 307

  Fly   342 TQLGGFKLVVGDPLGFLPSHPASLATNSSL-ALPMIIGATKDASAFIVSRIY-DQLARLQSRNVS 404
            |..|   :|.|.   |||.||..|..:... .:|.|||...|...:|:..:: |...:..:|
  Rat   308 TISG---VVDGK---FLPRHPLELLASVDFHPVPSIIGINSDEYGWIIPMLHPDSTMKEINR--- 363

  Fly   405 DYIDVVLRHTA-----PPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVIN 464
            :.:..||::||     ||....|     |.|.:....|.:.:||.   ...|:....::..|.:
  Rat   364 ETMRAVLKNTAVQMMLPPECSDL-----LMEEYMGDTEDSKTLQI---QFNEMMGDFIFVIPAL- 419

  Fly   465 SISQSYRS-VPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYL---------FPYPPEAS 519
            .::...|| .|.|.|.|     .|:...|.:..|..|.|...|:..|:         |.:..|
  Rat   420 QVAHFQRSHAPVYFYEF-----QHQSNFLKDIRPPHVKADHGDELPYVIGYLFWDMKFVFTEE-- 477

  Fly   520 RLNPLDRSLSRALVTMWVNFATTGVPNPSSGV--WPQATSEYGPFLRFTNNQQSPLELDPHFGEG 582
                 ::.|||.::..|.|||..|.|| |.|:  ||....:         .|...|::.|..|..
  Rat   478 -----EKLLSRKMIKYWANFARHGNPN-SEGLPYWPALDHD---------EQYLQLDIQPVVGRA 527

  Fly   583 I 583
            :
  Rat   528 L 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	152/564 (27%)
		Aes	<146..345	CDD:223730	65/208 (31%)
		RILP-like	<677..>717	CDD:304877
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	151/562 (27%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	40/108 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840