Protein Alignment Glt and Nlgn1

DIOPT Version :10

• Sequence 1: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 704
• Identity: 180/704 - (25%)
• Similarity: 265/704 - (37%)
• Gaps: 199/704 - (28%)

  Fly    68 GQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQSPNCAQ--- 125
            |:|.||.  |.:.|.   ||..|||:.|.....|..|||..:|......: |||..:|.|.|
Mouse    60 GKIRGIK--KELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQNII 122

  Fly   126 ---FPE----------LDRLRLSESRGENVDDCLTLDIYAP------------------------ 153
               .||          ||  .:|....:..:|||.|:||.|
Mouse   123 DGRLPEVMLPVWFTNNLD--VVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGG 185

  Fly   154 -------------EGANQ---------LPVLVFVHGEM-------LFDGGSEEAQPDYVLEK--D 187
                         :||..         .||:|::||..       |:||.        ||..  :
Mouse   186 PLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGS--------VLASYGN 242

  Fly   188 VLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLA 252
            |:::::||||...||||.......||..|.||..||.|...|:..|||:..::|:.|...|.:..
Mouse   243 VIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCV 307

  Fly   253 HALSLSGRA-GN--------LFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQ 308
            :.|:||..: ||        |||:.|.||||||:.:.:..||       |:.||.....:..:..
Mouse   308 NLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQP-------AKYARILATKVGCNVS 365

  Fly   309 GLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSS-LA 372
            ....|.:||.:.|       :::|:.|:.......:....::.||   .:|..|..|..... |.
Mouse   366 DTVELVECLQKKP-------YKELVDQDVQPARYHIAFGPVIDGD---VIPDDPQILMEQGEFLN 420

  Fly   373 LPMIIGATKDASAFIVSRIYDQLARLQSRN----VSDYID---------VVLRHTAPPSEHRLWK 424
            ..:::|..:......|..|.|....:.:.:    ||:::|         .|||.|.    ..::.
Mouse   421 YDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVLRETI----KFMYT 481

  Fly   425 QWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINS--ISQSYRSVPAYLYTFDYRGEHH 487
            .||.|.          :.:|....||.|.....:.||.:.:  :..::.| |.|.|.|    .||
Mouse   482 DWADRH----------NPETRRKTLLALFTDHQWVAPAVATADLHSNFGS-PTYFYAF----YHH 531

  Fly   488 RFGHLSNPLPFGVDASLSDDSVYLFPYP---PEASRLNPL-----DRSLSRALVTMWVNFATTGV 544
               ..::.:|...||:..|:..|:...|   |  :.|.|.     |..||..::|.|.|||.||.
Mouse   532 ---CQTDQVPAWADAAHGDEVPYVLGIPMIGP--TELFPCNFSKNDVMLSAVVMTYWTNFAKTGD 591

  Fly   545 PNPSSGVWPQATS---------EYGPFLRFTNNQQSPLE--LDPHFGEGIYLPNYR--------- 589
            ||...   ||.|.         |...:.|::...|..|.  |.|...|     :||
Mouse   592 PNQPV---PQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKE-----HYRANKVNLWLE 648

  Fly   590 -VIYKPTTNFSPPITTTTTTTTTTTTTSRPYAYN--------PYANWQNRPSQQ 634
             |.:....|.....|:|||...:|..|.||...|        |.|. |:.|.||
Mouse   649 LVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAK-QDDPKQQ 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_477504.1	COesterase	58..579	CDD:395084	160/629 (25%)
		Casc1_N	681..>717	CDD:464947
Nlgn1	XP_006535478.1	COesterase	52..646	CDD:395084	163/646 (25%)