DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and cest-28

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	132/571 - (23%)
Similarity:	227/571 - (39%)	Gaps:	121/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 IANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQSPNCAQF-PELDRLRLSESRGEN 141
            |.::.|:.:|||.:..   .|.||:..:|.|....| :.|...|.|.|. |..:.:...:....:
Worm    31 IGDKTVDGYLGIPFAK---PLVRFKKPEPAGTWEEVRDCTKYGPRCPQSGPFAEAINFQKDDIPD 92

  Fly   142 VDDCLTLDIYA----PEGANQL-PVLVFVHGEMLFDGGSE-EAQPDY--------VLEKDVLLVS 192
            ..:||||::::    .:..|:. ||:|::||     ||.| .|..||        :..|||::|:
Worm    93 EANCLTLNVFSKISDSKNFNKTRPVMVYIHG-----GGYECSASRDYCDYSVAGTLPLKDVVVVT 152

  Fly   193 INYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSL 257
            :|||:...||.:......|||.||.||.|.|.|:|:::..|||:.|.:|:.||:.||.....|:|
Worm   153 LNYRVGILGFFTTGDTVCPGNFALWDLTLGLNWIQKHIESFGGDPGNITIFGQSAGAACVDLLAL 217

  Fly   258 SGRAGNLFQQLILQSGTALNPYLI--DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARL 320
            |..:.:||.::|:.||.||..|.:  .|........|||       .:.......:.|::.:...
Worm   218 SPHSRDLFNRVIVMSGGALCEYAVRTANSQAKVCYEFAR-------HLGYDGTNSQTLFNWMKSK 275

  Fly   321 PTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPS-----HPASLATNSSLALP---MII 377
            |..:                :.::.||::.....|.:.|:     .|.|| ....:..|   :::
Worm   276 PLEE----------------IEKMNGFQVPASGILAWTPNLDDDFFPKSL-DELRIGAPKKDIMM 323

  Fly   378 GATKDASAFIVSRIYDQLARLQSRN--VSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTA 440
            |..:....|....|.|....|::..  |::|      :.....:|....:..:.|.::...|.|.
Worm   324 GFAEHEGLFFEFLIKDPTPPLEALKLYVNEY------YKKDTGDHFEATRNKIIEFYSRNVEDTD 382

  Fly   441 SLQTVAPGLLELSNYILYRAPVINSISQSYR-SVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASL 504
            ...| ...|::.....|:.|.|.::.....: ....:||.|||          .||..||
Worm   383 EKST-KERLIDFVGDALFTAGVFDNAKNCLKHGNNVWLYIFDY----------CNPSGFG----- 431

  Fly   505 SDDSVYLFPYPPEASRLNPL--------------DRSLSRALVTMWVNFATTGVPNP-SSGVWPQ 554
            :.:....|..|...:.|..:              :..:...:.|::.|||..|.||. .|..|.:
Worm   432 NQEEFMTFVAPTHCTDLRYVLGEGLYSDFQPTEEEHKMIEKMTTIYSNFAKYGNPNEHGSSEWEK 496

  Fly   555 AT------------------SEYGP----FLRFTNNQQSPLELDPHFGEGI 583
            .|                  ::|.|    ||.....:...|| :..:|.|:
Worm   497 FTLDNPRRHFQISYPRGKMRNDYHPDRMKFLELIRAKNQNLE-NVVYGRGL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	130/565 (23%)
		Aes	<146..345	CDD:223730	61/214 (29%)
		RILP-like	<677..>717	CDD:304877
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	124/538 (23%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	44/114 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920