DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and ace-1

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_510660.1	Gene:	ace-1 / 181706	WormBaseID:	WBGene00000035	Length:	620	Species:	Caenorhabditis elegans

Alignment Length:	664	Identity:	153/664 - (23%)
Similarity:	257/664 - (38%)	Gaps:	144/664 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQP-IGYQGRVNATVQSPNCAQ-----FP 127
            ::|..:|      :|:..|.||.:.....|..||:..:| ..::..:|||....:|.|     |.
Worm    33 EVLSQTG------KPLTRFQGIPFAEPPVGNLRFKKPKPKQPWRIPLNATTPPNSCIQSEDTYFG 91

  Fly   128 ELDRLRLSESRGENVDDCLTLDIYAP---EGANQLPVLVFVHGEMLFDGGSEEAQPD---YVLEK 186
            :.....:..:..:..:|||.|::|.|   :...:|.|:|:|:|...:.|.:.....|   ..:|:
Worm    92 DFYGSTMWNANTKLSEDCLYLNVYVPGKVDPNKKLAVMVWVYGGGFWSGTATLDVYDGRILTVEE 156

  Fly   187 DVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATL 251
            :|:||::|||::.||||.....|.|||:.:.|..||::|:.:|:..|||:..::||.|::.||..
Worm   157 NVILVAMNYRVSIFGFLYMNRPEAPGNMGMWDQLLAMKWVHKNIDLFGGDLSRITLFGESAGAAS 221

  Fly   252 AHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLA------RCPPPS-INPSAQG 309
            .....||.::...|.:.|:|||:|.:|:.|  :|.|.  ..||..      :|...| |||.
Worm   222 VSIHMLSPKSAPYFHRAIIQSGSATSPWAI--EPRDV--ALARAVILYNAMKCGNMSLINPD--- 279

  Fly   310 LKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGF---KLVVGDPLGFLPSHPASLATNSSL 371
            ...:.||..|        |....|.:||...:.:.|.|   .:|.||.|  |.:...||...:..
Worm   280 YDRILDCFQR--------ADADALRENEWAPVREFGDFPWVPVVDGDFL--LENAQTSLKQGNFK 334

  Fly   372 ALPMIIGATKDASA-FIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPI 435
            ...::.|:.:|.|. |:..::.|..........:|:|          .:.:||    ::.:...:
Worm   335 KTQLLAGSNRDESIYFLTYQLPDIFPVADFFTKTDFI----------KDRQLW----IKGVKDLL 385

  Fly   436 QEQTASLQTVAPGLLELSNYILYRAPV-----IN------------------SISQSYRSVPAYL 477
            ..|....|.....:|.  .|.....||     ||                  :::.:......|.
Worm   386 PRQILKCQLTLAAVLH--EYEPQDLPVTPRDWINAMDKMLGDYHFTCSVNEMALAHTKHGGDTYY 448

  Fly   478 YTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLD--RSLSRALVTMWVNFA 540
            |.|.:|.....:......| .|.:.:      ::|..|....|.|..|  |.||...:..|.|||
Worm   449 YYFTHRASQQTWPEWMGVL-HGYEIN------FIFGEPLNQKRFNYTDEERELSNRFMRYWANFA 506

  Fly   541 TTGVPNP------SSGVWPQATSEYGPFLRFTNNQQSPLELDPHFGEG----------IYLPNYR 589
            .||.||.      :..|||:..|....::..|.....|..  ...|.|          .||||..
Worm   507 KTGDPNKNEDGSFTQDVWPKYNSVSMEYMNMTVESSYPSM--KRIGHGPRRKECAFWKAYLPNLM 569

  Fly   590 VIYKPTTNFSPPITTTTTTTTTTTTTSRPYAYNPYANWQNRPSQQHPNWHPADPEYVRAQEARQQ 654
            .......                         :||..|:    ||...|   ..||:...:...:
Worm   570 AAVADVG-------------------------DPYLVWK----QQMDKW---QNEYITDWQYHFE 602

  Fly   655 EFIREREQRRREQQ 668
            ::.|.:..|:.:.:
Worm   603 QYKRYQTYRQSDSE 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	137/563 (24%)
		Aes	<146..345	CDD:223730	65/211 (31%)
		RILP-like	<677..>717	CDD:304877
ace-1	NP_510660.1	COesterase	13..561	CDD:278561	139/575 (24%)
ace-1	NP_510660.1	Aes	<114..>249	CDD:223730	45/134 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840