DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and glit-1

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_508807.1	Gene:	glit-1 / 180747	WormBaseID:	WBGene00018878	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	677	Identity:	172/677 - (25%)
Similarity:	274/677 - (40%)	Gaps:	164/677 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 WLPEPLKPV----PWQSET---------RYAQPQEAVVQAPEVGQILGISGH------------- 76
            ::|.|.:||    |:::.|         :.....|.||:.| :|.|:|...|
Worm    20 FVPPPTRPVDLWDPFKTTTTPFPHGGVNQGLNRDEVVVRLP-LGDIVGKEVHLHNLPWTIHKDPT 83

  Fly    77 ---------------KTIANRPVNAFLGIRYGTVGGGLARFQAAQPI----GYQGRVNATVQSPN 122
                           |...|..|..|||:.|........||:..|.:    |.|..: |...:.:
Worm    84 EELPKDGTHFDPNPLKPKNNITVFTFLGVPYAEPPTSQRRFKPPQQLTVFPGKQPYL-AFNYAAS 147

  Fly   123 CAQFPELDRLRLSESRGENVD---------DCLTLDIYAPE----GANQLPVLVFVHGEMLFDGG 174
            |||..|       :|....||         |||.|:|::|:    .....||:||.||.....|.
Worm   148 CAQDVE-------KSPSPFVDHPYPFMVDEDCLYLNIFSPDISKNAQTTYPVIVFFHGGNFQTGS 205

  Fly   175 SEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQ 239
            :.|.....:..:.:::|::||||..|||:| :.|...||..|.|.:||||:::.|:|.|||:...
Worm   206 ANEWPAHGLASRGMVVVTVNYRLGAFGFMS-MGDSETGNYGLQDQRLALEFVKNNIVTFGGDPQA 269

  Fly   240 VTLVG-QAGGATLA-HALSLSGRAGNLFQQLILQSGTALNPY-LIDNQPLDTLST--FARLARCP 299
            ||:|| .||.|::. |..|...|  :||:.....||..::.: .|....|...:|  ..|.|.|
Worm   270 VTVVGHDAGAASIGFHMQSPYSR--HLFRSAATMSGAEVSYHSYIGKTALAFNNTMKLGRYAGC- 331

  Fly   300 PPSINPSAQGL-KPLYDCLARLPTSQLVAAFEQLLLQ-NEHLGLTQLGGFKLVVGDPLGFLPSHP 362
                   .|.: :..:||:....|..::.|...:.:: |.:|.:..:.| |.:.|:||..|.:.|
Worm   332 -------TQAVAQHRWDCILTRSTGDIIDATRNIPIEYNRYLFMPTVDG-KYLPGNPLWTLVNAP 388

  Fly   363 ASLATNSSLALPMIIGA-TKDASAFIVS--RI--YDQLARLQSRNVSDY-IDVVLRHT------- 414
            :. .|:....:||:||. .:|.|..::.  |:  :.|...:....:..| ::...||.
Worm   389 SG-ETSIMSPVPMLIGMNAQDGSEVVLEDRRLGEFSQFNDVDHEYLKSYSLEYCYRHNYSMNREA 452

  Fly   415 ---APPSEHRLWKQ----WALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRS 472
               |..|::..|..    ||::|.|  ||..|.:..| ||  ::||:::         .|.|...
Worm   453 TADAILSKYTFWPDRAAAWAIKENF--IQFATDAYYT-AP--MQLSSHL---------HSSSGSR 503

  Fly   473 VPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYL-FPYPPEASRLNPL----------DR 526
            |..|:..:::..:|...  |..|...||   ..|..:|| |.||.....|.|:          ||
Worm   504 VFQYVNNYNFSRQHPNL--LFIPDWMGV---CRDCDLYLMFGYPFLPDELRPIGLRGINFTDTDR 563

  Fly   527 SLSRALVTMWVNFATTGVPN-PSSGVWPQATSEYGP----FLRFTNNQQ------SPLELDPHFG 580
            :.||....:...|:....|| ...|.|    :.|.|    ::.|....:      ..|..|..:.
Worm   564 NASRTFSNIIRRFSYHQNPNFQFDGSW----AAYEPRRHWYINFNYTHEEDWKIPGTLARDYRYQ 624

  Fly   581 E----GIYLP---NYRVIYKPTTNFSP 600
            :    ..|:|   ||.     ||.|||
Worm   625 DVAFWNEYIPALVNYM-----TTTFSP 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	157/617 (25%)
		Aes	<146..345	CDD:223730	62/209 (30%)
		RILP-like	<677..>717	CDD:304877
glit-1	NP_508807.1	COesterase	56..629	CDD:365897	156/617 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000