DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and cest-35.2

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_504398.1	Gene:	cest-35.2 / 178910	WormBaseID:	WBGene00016863	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	128/517 - (24%)
Similarity:	201/517 - (38%)	Gaps:	122/517 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VNAFLGIRYGTVGGGLARFQAA-------QPIGYQGRVNATVQSPNCAQFPELDRLRLSESRGEN 141
            ||.:|||.:.....|..||:.:       ||:      :.....|.|.|...|..|.:|::...:
Worm    36 VNGYLGIPFAKAPIGDLRFKKSVEAEKWTQPL------DCYKYGPGCPQSAALGALMVSQATNHD 94

  Fly   142 V--DDCLTLDIYAP-----EGANQLPVLVFVHGEMLFDGGSEEAQPDYVLE-----KDVLLVSIN 194
            .  |:||.|:::||     |..|..||:|:.:|.. |:.|......||.|.     |||:||:.|
Worm    95 FAEDNCLNLNVFAPKWKSAEFPNGFPVMVYFYGGG-FEVGFSSMFDDYSLTGTLPLKDVILVTPN 158

  Fly   195 YRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSG 259
            ||:.|.||.:...|...||..|.|..|||:|:|:::..|||:...||:.|.:.|......||||.
Worm   159 YRIGPLGFFATGDDVARGNWGLWDQALALQWVQKHIKSFGGDPSNVTISGTSAGGASVDFLSLSP 223

  Fly   260 RAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPS-----------------A 307
            .|...||:.|..||.|..|:.|.::.::.| .|...|.....:.|.|                 |
Worm   224 HANKYFQKFIPMSGAATCPFGIRSKDVEGL-IFREFANHHGYTGNDSKSLLQWYQSQDSEIFLKA 287

  Fly   308 QGLKPLYDCLARLPTSQLVA------------AFEQLLLQNEHLG-LTQLGGFKLVVGDPLGFLP 359
            :|    |.|    |.|.:.:            .|::|..:...|| :..:|.:     :.|||..
Worm   288 EG----YKC----PASGMFSFVPNFDGDFFPKPFDELRKEAPKLGAIVSIGEY-----EGLGFED 339

  Fly   360 SHPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWK 424
            .:                ...|.....:.:.:..::.|.:...|....:..|::....:|..:.|
Worm   340 FY----------------AGQKTPQQMLSAALGPEVVRNREEVVKRAAESYLKNGGNENEENIAK 388

  Fly   425 QWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRF 489
              .|.|||........:..||. .|::..|.:                   |||:|:|...
Worm   389 --TLVEIFGDYYFSVGAFDTVR-SLVKYGNTV-------------------YLYSFNYFNP---- 427

  Fly   490 GHLSNPLPFGVD-----ASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPN 546
               :.|:.||.:     |:...|..|:|  .......:..||.:...:.|...|||..|.||
Worm   428 ---NTPIVFGKNRPFNAANHGSDLRYIF--GEGTGEFSKEDRQVMDMMGTYHTNFAKYGNPN 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	128/517 (25%)
		Aes	<146..345	CDD:223730	71/238 (30%)
		RILP-like	<677..>717	CDD:304877
cest-35.2	NP_504398.1	COesterase	14..515	CDD:278561	128/517 (25%)
cest-35.2	NP_504398.1	Aes	<105..>239	CDD:223730	51/134 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850