DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and cest-32

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	147/571 - (25%)
Similarity:	228/571 - (39%)	Gaps:	112/571 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PEVG-QILGISGHKTIAN------RPVNAFLGIRYGTVGGGLARFQAAQPI---GYQGRVNATVQ 119
            ||.. ::|..|....|.|      :.||.:|||.:........||:  :|:   .:...:|....
Worm    10 PEASLEVLNASCGPVIGNIYRHDDKIVNGYLGIPFAKAPICELRFK--KPVEAEKWTKPLNCHKY 72

  Fly   120 SPNCAQFPELDRLRLSESRGENVDD-CLTLDIYAP-----EGANQLPVLVFVHGEMLFDGGSEEA 178
            .|.|.|...:....|.....|..:| ||.|:|:||     |..|.||::|:.||.. |:.|....
Worm    73 GPGCPQSGHMISNLLPPGYREFAEDNCLNLNIFAPSWKSEEFPNGLPIMVYFHGGG-FEIGFSSM 136

  Fly   179 QPDYVLE-----KDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAG 238
            ..||.|.     |||::|:.|||:.|.||::...:...||..|.|..|||:|:|.::..||||..
Worm   137 FDDYSLSGTLPLKDVIVVTANYRVGPLGFMTTGDEVSRGNYGLWDQTLALKWVQEHIKSFGGNPN 201

  Fly   239 QVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI--DNQPLDTLSTFARLARCPPP 301
            .||:.|.:.|...|..|:||..:..||.:.:..||:|...:.|  ..|..:....||:
Worm   202 IVTVCGTSAGGVSAGLLALSPHSNKLFHRFMAMSGSAFCEFSIRTKEQEAEIFRNFAK------- 259

  Fly   302 SINPSAQGLKPLYDCLARLPTS--QLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPS---- 360
            ......:..:.|.:.....|.|  |..|.||:           :..||       |.|:|:
Worm   260 HHGYEGEDSESLLEWYKSQPLSKFQETATFEK-----------KASGF-------LTFIPNFDGD 306

  Fly   361 -HPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARL---QS-RNVSDYI------DVVLRHT 414
             .|......|..|..:...||.|.        |:.|..|   || ||..|.|      |||
Worm   307 FFPKPFDELSREAPKLDAMATVDE--------YEGLGFLTMFQSRRNDMDIIKSSFGSDVV---- 359

  Fly   415 APPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSI--SQSYRSVPAYL 477
                |:.:..|..:.|.:....::... :.|...|::|.:...:....:.::  |..|.| .|||
Worm   360 ----ENAVDVQKRIMEFYMKNIDKNDD-KAVEKRLIQLISDSWFNIGALETVKTSTKYGS-NAYL 418

  Fly   478 YTFDYRGEHHRFGHLSNP----LPFGVDASLSDDSVYLF-----PYPPEASRLNPLDRSLSRALV 533
            .:|||    :..|. ::|    .||.. |:...:..|:.     .:.|.......:|     .:.
Worm   419 GSFDY----YNMGS-NDPYATWFPFKA-ANHGSELKYMLGEGMGKFSPIEEEFKVID-----MMG 472

  Fly   534 TMWVNFATTGVPNPSSG--VWPQATSEYGPFLRFTNNQQSPLELDPHFGEG 582
            |:..||...|.||..:|  :|.:.|.| .|:..|..:.... |:..:|.:|
Worm   473 TLTANFVKYGNPNGINGPELWKKYTPE-KPYSYFKIDYPKS-EMRDNFQDG 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	145/566 (26%)
		Aes	<146..345	CDD:223730	64/212 (30%)
		RILP-like	<677..>717	CDD:304877
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	143/559 (26%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	46/123 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840