DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and ace-3

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_496963.1	Gene:	ace-3 / 175076	WormBaseID:	WBGene00000037	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	137/552 - (24%)
Similarity:	224/552 - (40%)	Gaps:	109/552 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SETRYAQPQEAVVQA-PEVGQILGI-SGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPI-GYQ 111
            |..:..:|:.:||:. .::|.:.|. |.|   .|:.|.:|||:.:........||:...|. .:.
Worm    20 STAQQDEPKASVVEVQTKLGTVRGTESDH---GNKRVRSFLGVPFAEPPINEHRFKKPTPARPWN 81

  Fly   112 GRVNATVQSPNCAQ-----FPELDRLRLSESRGENVDDCLTLDIYAPEGANQLPVLVFVHGEMLF 171
            |.::|...||.|.|     .|......:..:.....:|||.::|:||..|..|.|||:     ||
Worm    82 GTISANTLSPACFQGRDSYDPTFWGSEMWNANTPVSEDCLYVNIWAPADAYNLTVLVW-----LF 141

  Fly   172 DGGSEEAQPDYVL--------EKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQR 228
            .||.....|..:|        ..:|::|:||||:.|||:|....:::|||:.:.|.||||.|::.
Worm   142 GGGFWYGSPSLLLYDGKELATRGNVIVVNINYRVGPFGYLFLDHEDVPGNMGMLDQQLALYWIRD 206

  Fly   229 NVVHFGGNAGQVTLVGQAGGAT--LAHALSLSGRAGNLFQQLILQSGTALNPYLIDN--QPLDTL 289
            ::..||||..:::|||::.||.  :||.::.:.:  .|||..|||||:..|.:.:|:  :.....
Worm   207 HIFSFGGNPARISLVGESAGAASIVAHLIAPASK--GLFQNGILQSGSLDNKWSMDSPKRAKQKS 269

  Fly   290 STFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQN-EHLGLTQLG-GFKLVVG 352
            :..|.|..|....|.....       ||...|.        |||:.| .::||..|. .|.:|..
Worm   270 TALADLVGCNQTKITDQTA-------CLRNTPA--------QLLIDNIWNVGLNFLEFPFAIVSK 319

  Fly   353 DPL------GFLPSHPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVL 411
            |..      ||:.....:.:|:.:|    :.|...|...|  ..||         |::.:.|
Worm   320 DQNFFKHLDGFIALREGTYSTDVNL----MFGINHDEGNF--WNIY---------NLAKFFD--- 366

  Fly   412 RHTAPPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINS--------ISQ 468
            :.:..|...|           ....|...:...|.|.|:..:...:|..|....        ..|
Worm   367 KQSVKPGLDR-----------DEFHECVDTAFAVQPELVRTAAKYVYSDPKCTDPKKKTDFYTEQ 420

  Fly   469 SYRSVPAYLYTFDYRGEHHRFGHL-----------------SNPLP--FGVDASLSDDSVYLFPY 514
            ..:.|..|.:|.|.....|.:..:                 :||.|  .||......:.|:..|.
Worm   421 VNQMVGDYFFTCDSIWFAHNYPKMAGNQSNVFVYYFDQPSSANPWPKWTGVMHGYEIEYVFGVPL 485

  Fly   515 PPEASRLNPLDRSLSRALVTMWVNFATTGVPN 546
            ....:.....:..:|..::..|..||.||||:
Worm   486 HNTTAGYTKEEMDVSEKVIDFWTTFANTGVPS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	136/547 (25%)
		Aes	<146..345	CDD:223730	68/211 (32%)
		RILP-like	<677..>717	CDD:304877
ace-3	NP_496963.1	COesterase	28..564	CDD:278561	135/544 (25%)
ace-3	NP_496963.1	Aes	<123..>234	CDD:223730	43/115 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840