DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and ace-4

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_496962.1	Gene:	ace-4 / 175074	WormBaseID:	WBGene00000038	Length:	602	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	146/568 - (25%)
Similarity:	226/568 - (39%)	Gaps:	128/568 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF-QAAQPIGYQGRVNATVQ 119
            |....||...::|.|.|....  ..::.:..|.|:.:........|| :..:...::|..:||
Worm    22 QAVHPVVLETKLGDIKGTEFF--FLSKKIRTFFGVPFAEPAVEDFRFRKPREKKQWRGLYDAT-- 82

  Fly   120 SPNCAQFPELDRLRL----SESRGENV---DDCLTLDIYAPEGANQLPVLVFVHGEMLFDGGSEE 177
            .|..|.|...|....    ||....|.   :|||.|:|:||..|..|.|:|:     .|.||...
Worm    83 KPANACFQTRDNYNTSFWGSEMWNANTQISEDCLYLNIWAPADAYNLTVMVW-----FFGGGFYS 142

  Fly   178 AQPDYVL--------EKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFG 234
            ..|...:        .::|::|:|||||.|||||.....:.|||:.|.|.||||.|:::|:|.||
Worm   143 GSPSLSIYDGKALTSTQNVIVVNINYRLGPFGFLYLGHPDAPGNMGLLDQQLALHWVRQNIVSFG 207

  Fly   235 GNAGQVTLVGQAGGAT--LAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPL---DTLSTFAR 294
            ||..:|.:.||:.||.  :||.::...|  .||:..|||||:..|.:.| |.|.   ........
Worm   208 GNPDKVAVFGQSAGAASIVAHLIAPGSR--GLFKNAILQSGSLENTWAI-NSPFRAKQKSEKLLE 269

  Fly   295 LARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLG-GFKLVVGDP--LG 356
            |..|...:::.|..       ||      :||:. |||.|...::.||.|. .|.:|..|.  .|
Worm   270 LVGCNKTTVDTSMA-------CL------RLVSP-EQLSLSTWNISLTYLEFPFVIVSRDKHFFG 320

  Fly   357 FLPSHPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHR 421
            .|.:|.|....:.:..:.::||..||...:  ..||         .:..:.|     .|.|.|..
Worm   321 HLDAHAALREGDFNRDVNLMIGMNKDEGNY--WNIY---------QLPQFFD-----KADPPELN 369

  Fly   422 LWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAP--------------VINSI------ 466
                   |..|..:.::|.|:|   |.::..:...:|..|              .:|.|
Worm   370 -------RTEFDFLIDRTFSIQ---PDIIRSAAKYIYSDPNCTDHGRKTRFYAGQMNQIVGDYFF 424

  Fly   467 -------SQSYRSVP-------------AYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYL 511
                   :..:||:|             .::|.|.....       :||.|....|....:..|:
Worm   425 SCDSLWLADQFRSIPRVKSSSPQRKPGKVFVYHFTQSSS-------ANPWPKWTGAMHGYEIEYV 482

  Fly   512 FPYPPEASR-LNPLDRSLSRALVTMWVNFATTGVPN----PSSGVWPQ 554
            |..|...|: ....::..||.::..|.:||..|.|.    .:|..||:
Worm   483 FGIPLSYSKNYKRREQIFSRKIMQFWASFAKNGTPKLRVLKNSEHWPE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	146/568 (26%)
		Aes	<146..345	CDD:223730	73/211 (35%)
		RILP-like	<677..>717	CDD:304877
ace-4	NP_496962.1	COesterase	28..562	CDD:278561	144/562 (26%)
ace-4	NP_496962.1	Aes	<120..>243	CDD:223730	49/129 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840